Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076004517> ?p ?o ?g. }
- W2076004517 abstract "Significance Calcium is an important intracellular second messenger that regulates many biological processes. Many extracellular environmental cues lead to cellular calcium-level changes, which impact on the output of gene expression. In cardiomyocytes, calcium is known to control gene expression at the level of transcription, whereas its role in regulating alternative splicing has not been explored. Our studies demonstrate that in these cells a network of alternatively spliced exons exists, which responds to the altered calcium levels by changing their splicing patterns. Our studies further elucidate an epigenetic regulatory mechanism, triggered by calcium signaling pathways, that leads to histone hyperacetylation along gene bodies, which increases the transcriptional elongation rate of RNA polymerase II and impacts alternative splicing." @default.
- W2076004517 created "2016-06-24" @default.
- W2076004517 creator A5003323462 @default.
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- W2076004517 date "2014-11-03" @default.
- W2076004517 modified "2023-10-09" @default.
- W2076004517 title "Calcium-mediated histone modifications regulate alternative splicing in cardiomyocytes" @default.
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- W2076004517 doi "https://doi.org/10.1073/pnas.1408964111" @default.
- W2076004517 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4246288" @default.
- W2076004517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25368158" @default.
- W2076004517 hasPublicationYear "2014" @default.
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