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• W2076008148 abstract "Abstract Two human cell lines (HEC-1, IFr) which are resistant to the anticellular and/or antiviral action of HuIFN-α or -β have been tested with respect to the anticellular and antiviral activities of HuIFN-γ. HEC-1 cells were totally resistant to the antiviral activity of the IFN-γ, with either EMC or VSV as challenge virus. Per antiviral unit HuIFN-γ exerted a much stronger inhibitory effect on the growth of the interferon-sensitive cell line RSa than did IFN-α. IFr cells were more resistant to the anticellular effect of IFN-γ than the wild-type cells (RSa), and HEC-1 cells were totally resistant to the anticellular effect of HuIFN-γ. 2-5A synthetase was present at a high basic level in untreated HEC-1 cells, as previously reported. This activity was not influenced by either HuIFN-β or -γ. Similar levels of 2-5A synthetase were induced by HuIFN-γ in IFr and RSa cells; however, this induction was 10 times lower than that obtained for HuIFN-β. A 2′-phosphodiesterase activity was detected in control extracts from RSa and was not induced by either HuIFN-β or -γ. There was no correlation between the amplitude of 2-5A synthetase induction and extent of anticellular effect of either HuIFN-γ in different cell lines or of different interferons in a given cell line. Finally, HEC-1 represents the first example of a human cell line which is resistant to all three types of interferon (HuIFN-α, -β, and -γ)." @default.
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• W2076008148 date "1982-03-01" @default.
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• W2076008148 title "2-5A synthetase activity induced by interferon α, β, and γ in human cell lines differing in their sensitivity to the anticellular and antiviral activities of these interferons" @default.
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• W2076008148 doi "https://doi.org/10.1016/0042-6822(82)90481-0" @default.
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