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- W2076010627 abstract "Non-nucleoside reverse transcriptase inhibitors (NNRTIs) have been used widely for treating human immunodeficiency virus type 1 (HIV-1) infected patients as a component of highly active antiretroviral therapy (HAART) and for the prevention of mother-to-child transmission (MTCT). Cytochrome P450 (CYP) 2B6 is an important hepatic isoenzyme responsible for the metabolism of NNRTIs including efavirenz and nevirapine. Recent pharmacogenetic studies have shown that CYP2B6 genetic variants alter hepatic CYP2B6 protein expression and function, and the pharmacokinetics of several CYP2B6 substrates. In particular, the CYP2B6-G516T polymorphism in exon 4 affects the pharmacokinetics of efavirenz. Other studies have shown associations of the CYP2B6-G516T genotype with nevirapine pharmacokinetics and central nervous system adverse effects related to efavirenz use. In total, CYP2B6 genetic variants are important determinants of efavirenz and nevirapine pharmacokinetics . Further studies are needed to identify the associations of CYP2B6 genetic variants with the development of NNRTI resistant viruses." @default.
- W2076010627 created "2016-06-24" @default.
- W2076010627 creator A5017306542 @default.
- W2076010627 creator A5085906843 @default.
- W2076010627 date "2008-01-01" @default.
- W2076010627 modified "2023-09-26" @default.
- W2076010627 title "Effect of host genetic variation on the pharmacokinetics and clinical response of NNRTIs" @default.
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- W2076010627 doi "https://doi.org/10.2217/17469600.2.1.69" @default.
- W2076010627 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3010754" @default.
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