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• W2076013273 abstract "The attractive interaction between basic protein domains and membranes containing acidic lipids is critical to the membrane attachment of many proteins involved in cell signaling. In this study, a series of charged model peptides containing lysine, phenylalanine, and the spin-labeled amino acid tetramethyl-piperidine-N-oxyl-4-amino-4-carboxylic acid (TOAC) were synthesized, and electron paramagnetic resonance (EPR) spectroscopy was used to determine their position on the membrane interface and free energy of binding. When membrane-bound, peptides containing only lysine and TOAC assume an equilibrium position within the aqueous double layer at a distance of approximately 5 A from the membrane interface, a result that is consistent with recent computational work. Substitution of two or more lysine residues by phenylalanine dramatically slows the backbone diffusion of these peptides and shifts their equilibrium position by 13-15 A so that the backbone lies several angstroms below the level of the lipid phosphate. These results are consistent with the hypothesis that the position and free energy of basic peptides when bound to membranes are determined by a long-range Coulombic attraction, the hydrophobic effect, and a short-range desolvation force. The differences in binding free energy within this set of charged peptides is not well accounted for by the simple addition of free energies based upon accepted side chain partition free energies, a result that appears to be in part due to differences in membrane localization of these peptides." @default.
• W2076013273 created "2016-06-24" @default.
• W2076013273 creator A5028973291 @default.
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• W2076013273 date "2001-10-01" @default.
• W2076013273 modified "2023-10-10" @default.
• W2076013273 title "Location and Dynamics of Basic Peptides at the Membrane Interface: Electron Paramagnetic Resonance Spectroscopy of Tetramethyl-Piperidine-N-Oxyl-4-Amino-4-Carboxylic Acid-Labeled Peptides" @default.
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• W2076013273 doi "https://doi.org/10.1016/s0006-3495(01)75871-7" @default.
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