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• W2076015891 endingPage "56" @default.
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• W2076015891 abstract "Imidacloprid, a neonicotinoid the newest class of major insecticide has outstanding potency and systemic action for crop protection against piercing and sucking insects pests and also highly effective for control of flea on cats and dogs. The effect of oral administration of two doses of imidacloprid 10 and 20 mg/kg/day for 60 days on biochemical parameters, histopathology and protein profile of female albino rat was assessed. Average feed intake was significantly reduced (P < 0.01) at 20 mg/kg/day. Relative weight of heart and spleen decreased significantly (P < 0.05) at higher dose level. Non significant increase in alanine aminotransferase (ALT), aspartate aminotransferase (AST), acid phosphatase (ACP), alkaline phosphatase (AKP) activity was observed in both the imidacloprid treated groups. There was significant decrease (P < 0.01, P < 0.05) in acetyl cholinesterase (AChE) activity in plasma and brain of both the imidacloprid treated groups. Microscopically, liver tissue of rats treated with higher dose of imidacloprid showed marked dilation and congestion of central vein and degeneration of hepatocytes. The exposure to imidacloprid produced histopathological changes that could be correlated with changes in the biochemical profile of female albino rats. The blood plasma proteins were examined by SDS PAGE. There was no diagnostic difference in the pattern of plasma protein profile of control and treated rats. Based on the present physiological, biochemical and histological studies it is evident that imidacloprid did not produce any significant effects at 10 mg/kg/day dose but induced toxicological effects at 20 mg/kg/day to female rats." @default.
• W2076015891 created "2016-06-24" @default.
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• W2076015891 date "2014-03-01" @default.
• W2076015891 modified "2023-09-23" @default.
• W2076015891 title "Physiological, biochemical and histological alterations induced by administration of imidacloprid in female albino rats" @default.
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• W2076015891 doi "https://doi.org/10.1016/j.pestbp.2014.02.007" @default.
• W2076015891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24759051" @default.
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