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- W2076017230 abstract "Understanding how the limb blastema is established after the initial wound healing response is an important aspect of regeneration research. Here we performed parallel expression profile time courses of healing lateral wounds versus amputated limbs in axolotl. This comparison between wound healing and regeneration allowed us to identify amputation-specific genes. By clustering the expression profiles of these samples, we could detect three distinguishable phases of gene expression – early wound healing followed by a transition-phase leading to establishment of the limb development program, which correspond to the three phases of limb regeneration that had been defined by morphological criteria. By focusing on the transition-phase, we identified 93 strictly amputation-associated genes many of which are implicated in oxidative-stress response, chromatin modification, epithelial development or limb development. We further classified the genes based on whether they were or were not significantly expressed in the developing limb bud. The specific localization of 53 selected candidates within the blastema was investigated by in situ hybridization. In summary, we identified a set of genes that are expressed specifically during regeneration and are therefore, likely candidates for the regulation of blastema formation." @default.
- W2076017230 created "2016-06-24" @default.
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- W2076017230 date "2013-05-01" @default.
- W2076017230 modified "2023-10-17" @default.
- W2076017230 title "Comparative Transcriptional Profiling of the Axolotl Limb Identifies a Tripartite Regeneration-Specific Gene Program" @default.
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- W2076017230 doi "https://doi.org/10.1371/journal.pone.0061352" @default.
- W2076017230 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3641036" @default.
- W2076017230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23658691" @default.
- W2076017230 hasPublicationYear "2013" @default.
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