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- W2076019198 abstract "ALpha-synuclein (alpha-syn) has been known to be a key player of the pathogenesis of Parkinson's disease and has recently been detected in extracellular biological fluids and shown to be rapidly secreted from cells. The penetration of alpha-syn into cells has also been observed. In this study, we observed that dl-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol, a glucosyltransferase inhibitor, and proteinase K inhibited the internalization of extracellular monomeric alpha-syn into BV-2 cells, and the addition of monosialoganglioside GM1 ameliorated the inhibition of alpha-syn internalization in dl-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol-treated BV-2 cells. Furthermore, inhibition of clathrin-, caveolae-, and dynamin-dependent endocytosis did not prevent the internalization of alpha-syn, but disruption of lipid raft inhibited it. Inhibition of macropinocytosis and disruption of actin and microtubule structures also did not inhibit the internalization of alpha-syn. In addition, we further confirmed these observations by co-culture system of BV-2 cells and alpha-syn-over-expressing SH-SY5Y cells. These findings suggest that extracellular alpha-syn is internalized into microglia via GM1 as well as hitherto-unknown protein receptors in clathrin-, caveolae-, and dynamin-independent, but lipid raft-dependent manner. Elucidation of the mechanism involved in internalization of alpha-syn should be greatly helpful in the development of new treatments of alpha-syn-related neurodegenerative diseases." @default.
- W2076019198 created "2016-06-24" @default.
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- W2076019198 date "2009-06-15" @default.
- W2076019198 modified "2023-10-17" @default.
- W2076019198 title "On the mechanism of internalization of α-synuclein into microglia: roles of ganglioside GM1 and lipid raft" @default.
- W2076019198 cites W1502026371 @default.
- W2076019198 cites W1604776255 @default.
- W2076019198 cites W1886840778 @default.
- W2076019198 cites W1965778124 @default.
- W2076019198 cites W1967247889 @default.
- W2076019198 cites W1967289387 @default.
- W2076019198 cites W1970965394 @default.
- W2076019198 cites W1972759173 @default.
- W2076019198 cites W1976316003 @default.
- W2076019198 cites W1981426567 @default.
- W2076019198 cites W1981690836 @default.
- W2076019198 cites W1983591304 @default.
- W2076019198 cites W1984031632 @default.
- W2076019198 cites W1989999317 @default.
- W2076019198 cites W1994752272 @default.
- W2076019198 cites W1994845066 @default.
- W2076019198 cites W1999883522 @default.
- W2076019198 cites W2009296046 @default.
- W2076019198 cites W2013274873 @default.
- W2076019198 cites W2025922492 @default.
- W2076019198 cites W2026676471 @default.
- W2076019198 cites W2032842463 @default.
- W2076019198 cites W2033531401 @default.
- W2076019198 cites W2038634991 @default.
- W2076019198 cites W2045113959 @default.
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- W2076019198 cites W2050291058 @default.
- W2076019198 cites W2050786534 @default.
- W2076019198 cites W2057835051 @default.
- W2076019198 cites W2058403143 @default.
- W2076019198 cites W2066778206 @default.
- W2076019198 cites W2074484003 @default.
- W2076019198 cites W2077494883 @default.
- W2076019198 cites W2079333946 @default.
- W2076019198 cites W2089378200 @default.
- W2076019198 cites W2089900719 @default.
- W2076019198 cites W2089974427 @default.
- W2076019198 cites W2091265794 @default.
- W2076019198 cites W2103336276 @default.
- W2076019198 cites W2108060249 @default.
- W2076019198 cites W2109504418 @default.
- W2076019198 cites W2112032807 @default.
- W2076019198 cites W2112251510 @default.
- W2076019198 cites W2122564376 @default.
- W2076019198 cites W2123869107 @default.
- W2076019198 cites W2128631317 @default.
- W2076019198 cites W2130050860 @default.
- W2076019198 cites W2130779504 @default.
- W2076019198 cites W2133759882 @default.
- W2076019198 cites W2134272142 @default.
- W2076019198 cites W2137960852 @default.
- W2076019198 cites W2138306686 @default.
- W2076019198 cites W2138512196 @default.
- W2076019198 cites W2138529060 @default.
- W2076019198 cites W2139436990 @default.
- W2076019198 cites W2147461093 @default.
- W2076019198 cites W2149985631 @default.
- W2076019198 cites W2150651714 @default.
- W2076019198 cites W2150656456 @default.
- W2076019198 cites W2152624614 @default.
- W2076019198 cites W2154678377 @default.
- W2076019198 cites W2154737306 @default.
- W2076019198 cites W2156228214 @default.
- W2076019198 cites W2161591620 @default.
- W2076019198 cites W2161709410 @default.
- W2076019198 cites W2162353774 @default.
- W2076019198 cites W2394842998 @default.
- W2076019198 cites W4238726741 @default.
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- W2076019198 doi "https://doi.org/10.1111/j.1471-4159.2009.06150.x" @default.
- W2076019198 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19457104" @default.
- W2076019198 hasPublicationYear "2009" @default.
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