Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076038440> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2076038440 abstract "Abstract Tissue cultures of neonate rat heart cells were subjected to anoxia for 16 h in the presence of 5 m m glucose and increasing concentrations of calcium in the incubation medium. When the calcium content of the culture medium was increased, release of intracellular enzyme was observed. Increased extracellular calcium concentration appeared to have no effect on normoxic tissue preparations. The time course of this anoxia-related change was examined. Increasing the calcium concentration of the medium caused an acceleration of the anoxia-induced rate of enzyme leakage when compared with anoxic cultures exposed to a low medium calicum concentration. The calcium-induced increase in anoxic enzyme release could be partially reversed by various concentrations of the calcium antagonist drugs verapamil and nifedipine. Verapamil and nifedipine both appear to reduce the extent to which an elevated medium calcium concentration is able to reduce myocyte ATP content under anoxic conditions. These drugs appear to be without effect on ATP content of anoxic cells exposed to a low calcium concentration on the medium. Calcium-induced increases in enzyme leakage cannot be modified by the provision of high medium glucose concentrations, and hypertonic solutions of mannitol exacerbate damage to myocytes under anoxic and hypercalcaemic conditions. These data suggest that high extracellular concentrations of calcium exacerbate damage to heart cells subjected to anoxia although the mechanism underlying this exacerbation is uncertain." @default.
- W2076038440 created "2016-06-24" @default.
- W2076038440 creator A5030272915 @default.
- W2076038440 creator A5048971056 @default.
- W2076038440 creator A5053902400 @default.
- W2076038440 date "1980-09-01" @default.
- W2076038440 modified "2023-09-26" @default.
- W2076038440 title "The effect of extracellular calcium concentration and Ca-antagonist drugs on enzyme release and lactate production by anoxic heart cell cultures" @default.
- W2076038440 cites W140868171 @default.
- W2076038440 cites W1474748623 @default.
- W2076038440 cites W1528492966 @default.
- W2076038440 cites W180139333 @default.
- W2076038440 cites W1956064030 @default.
- W2076038440 cites W1977826512 @default.
- W2076038440 cites W1992325152 @default.
- W2076038440 cites W1998949580 @default.
- W2076038440 cites W2005287643 @default.
- W2076038440 cites W2019027868 @default.
- W2076038440 cites W2020567226 @default.
- W2076038440 cites W2023778659 @default.
- W2076038440 cites W2024466946 @default.
- W2076038440 cites W2025783912 @default.
- W2076038440 cites W2027163528 @default.
- W2076038440 cites W2030655590 @default.
- W2076038440 cites W2053093319 @default.
- W2076038440 cites W2059690641 @default.
- W2076038440 cites W2078150592 @default.
- W2076038440 cites W2083577226 @default.
- W2076038440 cites W2085202527 @default.
- W2076038440 cites W2092238408 @default.
- W2076038440 cites W2092267565 @default.
- W2076038440 cites W2146842880 @default.
- W2076038440 cites W2147109068 @default.
- W2076038440 cites W2169355421 @default.
- W2076038440 cites W2232642378 @default.
- W2076038440 cites W2615442733 @default.
- W2076038440 doi "https://doi.org/10.1016/0022-2828(80)90059-0" @default.
- W2076038440 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6777502" @default.
- W2076038440 hasPublicationYear "1980" @default.
- W2076038440 type Work @default.
- W2076038440 sameAs 2076038440 @default.
- W2076038440 citedByCount "41" @default.
- W2076038440 countsByYear W20760384402018 @default.
- W2076038440 crossrefType "journal-article" @default.
- W2076038440 hasAuthorship W2076038440A5030272915 @default.
- W2076038440 hasAuthorship W2076038440A5048971056 @default.
- W2076038440 hasAuthorship W2076038440A5053902400 @default.
- W2076038440 hasConcept C107872376 @default.
- W2076038440 hasConcept C108970007 @default.
- W2076038440 hasConcept C126322002 @default.
- W2076038440 hasConcept C134018914 @default.
- W2076038440 hasConcept C178790620 @default.
- W2076038440 hasConcept C181080969 @default.
- W2076038440 hasConcept C185592680 @default.
- W2076038440 hasConcept C207200792 @default.
- W2076038440 hasConcept C2777022698 @default.
- W2076038440 hasConcept C2779066535 @default.
- W2076038440 hasConcept C28406088 @default.
- W2076038440 hasConcept C519063684 @default.
- W2076038440 hasConcept C55493867 @default.
- W2076038440 hasConcept C71924100 @default.
- W2076038440 hasConcept C86803240 @default.
- W2076038440 hasConceptScore W2076038440C107872376 @default.
- W2076038440 hasConceptScore W2076038440C108970007 @default.
- W2076038440 hasConceptScore W2076038440C126322002 @default.
- W2076038440 hasConceptScore W2076038440C134018914 @default.
- W2076038440 hasConceptScore W2076038440C178790620 @default.
- W2076038440 hasConceptScore W2076038440C181080969 @default.
- W2076038440 hasConceptScore W2076038440C185592680 @default.
- W2076038440 hasConceptScore W2076038440C207200792 @default.
- W2076038440 hasConceptScore W2076038440C2777022698 @default.
- W2076038440 hasConceptScore W2076038440C2779066535 @default.
- W2076038440 hasConceptScore W2076038440C28406088 @default.
- W2076038440 hasConceptScore W2076038440C519063684 @default.
- W2076038440 hasConceptScore W2076038440C55493867 @default.
- W2076038440 hasConceptScore W2076038440C71924100 @default.
- W2076038440 hasConceptScore W2076038440C86803240 @default.
- W2076038440 hasLocation W20760384401 @default.
- W2076038440 hasLocation W20760384402 @default.
- W2076038440 hasOpenAccess W2076038440 @default.
- W2076038440 hasPrimaryLocation W20760384401 @default.
- W2076038440 hasRelatedWork W1977765199 @default.
- W2076038440 hasRelatedWork W1986558458 @default.
- W2076038440 hasRelatedWork W2019529003 @default.
- W2076038440 hasRelatedWork W2070444329 @default.
- W2076038440 hasRelatedWork W2084745859 @default.
- W2076038440 hasRelatedWork W2093903954 @default.
- W2076038440 hasRelatedWork W2133787581 @default.
- W2076038440 hasRelatedWork W2410003636 @default.
- W2076038440 hasRelatedWork W2418451365 @default.
- W2076038440 hasRelatedWork W2552805435 @default.
- W2076038440 isParatext "false" @default.
- W2076038440 isRetracted "false" @default.
- W2076038440 magId "2076038440" @default.
- W2076038440 workType "article" @default.