FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076042280> ?p ?o ?g. }

• W2076042280 endingPage "799" @default.
• W2076042280 startingPage "787" @default.
• W2076042280 abstract "Therapeutic vaccines for the treatment of cancer are an attractive alternative to some of the conventional therapies that are currently used. More importantly, vaccines could be very useful to prevent recurrences when applied after primary therapy. Unfortunately, most therapeutic vaccines for cancer have performed poorly due to the low level of immune responses that they induce. Previous work done in our laboratory in cancer mouse models demonstrated that vaccines consisting of synthetic peptides representing minimal CD8 T-cell epitopes administered i.v. mixed with poly-IC and anti-CD40 antibodies (TriVax) were capable of inducing massive T cell responses similar to those found during acute infections. We now report that some peptides are capable of inducing similarly large T cell responses after vaccination with poly-IC alone (BiVax). The results show that amphiphilic peptides are more likely to function as strong immunogens in BiVax and that systemic immunizations (i.v. or i.m.) were more effective than local (s.c.) vaccine administration. The immune responses induced by BiVax were found to be effective against established tumors in two mouse cancer models. The roles of various immune-related pathways such as type-I IFN, CD40 costimulation, CD4 T cells, TLRs and the MDA5 RNA helicase were examined. The present findings could facilitate the development of simple and effective subunit vaccines for diseases where CD8 T cells provide a therapeutic benefit." @default.
• W2076042280 created "2016-06-24" @default.
• W2076042280 creator A5022405393 @default.
• W2076042280 creator A5032554768 @default.
• W2076042280 creator A5048923977 @default.
• W2076042280 creator A5077239825 @default.
• W2076042280 creator A5089293871 @default.
• W2076042280 date "2012-12-25" @default.
• W2076042280 modified "2023-10-17" @default.
• W2076042280 title "BiVax: a peptide/poly-IC subunit vaccine that mimics an acute infection elicits vast and effective anti-tumor CD8 T-cell responses" @default.
• W2076042280 cites W1488583473 @default.
• W2076042280 cites W1522781268 @default.
• W2076042280 cites W1608778557 @default.
• W2076042280 cites W1951706783 @default.
• W2076042280 cites W1967425011 @default.
• W2076042280 cites W1968266972 @default.
• W2076042280 cites W1970464571 @default.
• W2076042280 cites W1972082634 @default.
• W2076042280 cites W1975304761 @default.
• W2076042280 cites W1975933747 @default.
• W2076042280 cites W1980704214 @default.
• W2076042280 cites W1992699637 @default.
• W2076042280 cites W2008853544 @default.
• W2076042280 cites W2010244581 @default.
• W2076042280 cites W2035151186 @default.
• W2076042280 cites W2035686689 @default.
• W2076042280 cites W2037625112 @default.
• W2076042280 cites W2062078150 @default.
• W2076042280 cites W2071244674 @default.
• W2076042280 cites W2080816681 @default.
• W2076042280 cites W2088335117 @default.
• W2076042280 cites W2098065670 @default.
• W2076042280 cites W2108011071 @default.
• W2076042280 cites W2124465622 @default.
• W2076042280 cites W2141853132 @default.
• W2076042280 cites W2153746213 @default.
• W2076042280 cites W2166582029 @default.
• W2076042280 cites W4244058959 @default.
• W2076042280 doi "https://doi.org/10.1007/s00262-012-1382-6" @default.
• W2076042280 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3625508" @default.
• W2076042280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23266830" @default.
• W2076042280 hasPublicationYear "2012" @default.
• W2076042280 type Work @default.
• W2076042280 sameAs 2076042280 @default.
• W2076042280 citedByCount "64" @default.
• W2076042280 countsByYear W20760422802013 @default.
• W2076042280 countsByYear W20760422802014 @default.
• W2076042280 countsByYear W20760422802015 @default.
• W2076042280 countsByYear W20760422802016 @default.
• W2076042280 countsByYear W20760422802017 @default.
• W2076042280 countsByYear W20760422802018 @default.
• W2076042280 countsByYear W20760422802019 @default.
• W2076042280 countsByYear W20760422802020 @default.
• W2076042280 countsByYear W20760422802021 @default.
• W2076042280 countsByYear W20760422802022 @default.
• W2076042280 countsByYear W20760422802023 @default.
• W2076042280 crossrefType "journal-article" @default.
• W2076042280 hasAuthorship W2076042280A5022405393 @default.
• W2076042280 hasAuthorship W2076042280A5032554768 @default.
• W2076042280 hasAuthorship W2076042280A5048923977 @default.
• W2076042280 hasAuthorship W2076042280A5077239825 @default.
• W2076042280 hasAuthorship W2076042280A5089293871 @default.
• W2076042280 hasBestOaLocation W20760422801 @default.
• W2076042280 hasConcept C121608353 @default.
• W2076042280 hasConcept C126322002 @default.
• W2076042280 hasConcept C154317977 @default.
• W2076042280 hasConcept C159047783 @default.
• W2076042280 hasConcept C159654299 @default.
• W2076042280 hasConcept C167672396 @default.
• W2076042280 hasConcept C195616568 @default.
• W2076042280 hasConcept C202751555 @default.
• W2076042280 hasConcept C203014093 @default.
• W2076042280 hasConcept C22070199 @default.
• W2076042280 hasConcept C2776090121 @default.
• W2076042280 hasConcept C2777701055 @default.
• W2076042280 hasConcept C502942594 @default.
• W2076042280 hasConcept C55493867 @default.
• W2076042280 hasConcept C71924100 @default.
• W2076042280 hasConcept C86803240 @default.
• W2076042280 hasConcept C8891405 @default.
• W2076042280 hasConceptScore W2076042280C121608353 @default.
• W2076042280 hasConceptScore W2076042280C126322002 @default.
• W2076042280 hasConceptScore W2076042280C154317977 @default.
• W2076042280 hasConceptScore W2076042280C159047783 @default.
• W2076042280 hasConceptScore W2076042280C159654299 @default.
• W2076042280 hasConceptScore W2076042280C167672396 @default.
• W2076042280 hasConceptScore W2076042280C195616568 @default.
• W2076042280 hasConceptScore W2076042280C202751555 @default.
• W2076042280 hasConceptScore W2076042280C203014093 @default.
• W2076042280 hasConceptScore W2076042280C22070199 @default.
• W2076042280 hasConceptScore W2076042280C2776090121 @default.
• W2076042280 hasConceptScore W2076042280C2777701055 @default.
• W2076042280 hasConceptScore W2076042280C502942594 @default.
• W2076042280 hasConceptScore W2076042280C55493867 @default.
• W2076042280 hasConceptScore W2076042280C71924100 @default.
• W2076042280 hasConceptScore W2076042280C86803240 @default.
• W2076042280 hasConceptScore W2076042280C8891405 @default.
• W2076042280 hasIssue "4" @default.

• next