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- W2076042488 abstract "In this study, we investigated whether there was a diurnal difference in mitogen-activated protein kinase (p42/44MAPK) phosphorylation in the rat pineal gland. Under a lighting regimen with 12 h of darkness, there was a two- to four-fold increase in phosphorylated levels of MAPK kinase 1/2 (MEK1/2) and p42/44MAPK 2 h after onset of darkness, an increase that was sustained for 8 h. The increases in phosphorylated levels of MEK1/2 and p42/44MAPK occurred without increases in MEK1/2 and p42/44MAPK proteins. When rats were treated with propranolol 1 h before onset of darkness or subjected to continuous light exposure during the dark phase, the nocturnal increase in MEK1/2 and p42/44MAPK phosphorylation was reduced. Acute light exposure during darkness caused a decline in MEK1/2 and p42/44MAPK phosphorylation within 30 min of light exposure. These results indicate the presence of a diurnal difference in MEK1/2 and p42/44MAPK phosphorylation in the rat pineal gland that is under adrenergic control." @default.
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- W2076042488 date "2003-10-31" @default.
- W2076042488 modified "2023-09-25" @default.
- W2076042488 title "Diurnal variation in p42/44 mitogen-activated protein kinase in the rat pineal gland" @default.
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- W2076042488 doi "https://doi.org/10.1016/s0303-7207(03)00260-0" @default.
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