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• W2076043178 abstract "SUMMARY The processes underlying expulsion of Hymenolepis diminuta in rats are not known. Expression levels of mRNAs of several cytokines revealed a Th2 response that differed between worm infection levels. IL‐4 protein levels decreased while IL‐13 levels increased in a 50‐worm infection by 30 dpi; the converse was seen with a five‐worm infection. A negative correlation was found between IL‐4 or IL‐13 mRNA expression and worm biomass, between IL‐13 protein levels and worm number or worm biomass, and between IL‐4 protein levels and worm biomass in 50‐worm infections. A negative correlation between IL‐4 mRNA or protein expression and worm biomass was observed with five‐worm infections. A strong correlation between Muc2 mRNA expression and decreased worm number or biomass in a 50‐worm infection was observed. Muc2 protein, goblet cell numbers and mucin decreased in a 50‐worm infection by 20 days post‐infection. These changes were not seen with five‐worm infections where worms are not expelled. The data show that rats infected with 50 H. diminuta mount a Th2 response leading to high levels of IL‐13, increased goblet cell numbers and increased mucin2 production and release. The mucus traps the worms, which are progressively expelled from the small intestine." @default.
• W2076043178 created "2016-06-24" @default.
• W2076043178 creator A5026917331 @default.
• W2076043178 creator A5035551973 @default.
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• W2076043178 date "2006-09-22" @default.
• W2076043178 modified "2023-10-10" @default.
• W2076043178 title "Expulsion of the gastrointestinal cestode, Hymenolepis diminuta by tolerant rats: evidence for mediation by a Th2 type immune enhanced goblet cell hyperplasia, increased mucin production and secretion" @default.
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• W2076043178 doi "https://doi.org/10.1111/j.1365-3024.2006.00908.x" @default.
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