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- W2076050606 abstract "Limbal stem cell (LSC) deficiency leads to corneal opacity due to a conjunctivalization of the corneal surface. LSC transplantation, which can be followed by corneal keratoplasty, is an effective procedure to restore corneal transparency; however, a common cause of failure of this procedure is neovascularization (NV).A 59-year-old man with a 21-year history of a corneal chemical burn caused by phosphoric acid in his left eye was examined. He presented with unilateral total LSC deficiency with severe conjunctivalization and a corrected distance visual acuity that was limited to hand motion.We reported the short-term in vivo efficacy of subconjunctival bevacizumab for progressive corneal NV in a patient with LSC deficiency that underwent LSC transplantation. Four months after autologous LSC transplantation and 1 month after the second subconjunctival bevacizumab injection, the patient's corrected distance visual acuity was 1/10.Subconjunctival injection of bevacizumab can reduce the corneal NV, reducing conjunctival inflammation and supporting restoration of a stable ocular surface that is able to counteract graft failure, with no toxicity for the transplanted LSC." @default.
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- W2076050606 date "2014-08-01" @default.
- W2076050606 modified "2023-10-18" @default.
- W2076050606 title "Chemical injury treated with autologous limbal epithelial stem cell transplantation and subconjunctival bevacizumab" @default.
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- W2076050606 doi "https://doi.org/10.2147/opth.s65298" @default.
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