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• W2076059045 abstract "The work presented here verifies the hypothesis that RS-α-lipoic acid may exert its cholinoprotective and cholinotrophic activities through the maintenance of appropriate levels of acetyl-CoA in mitochondrial and cytoplasmic compartments of cholinergic neurons. Sodium nitroprusside (SNP) and amyloid-β decreased pyruvate dehydrogenase, choline acetyltransferase activities, acetyl-CoA content in mitochondria and cytoplasm, as well as increased fraction of non-viable, trypan blue positive cells in cultured differentiated cholinergic SN56 neuroblastoma cells. Lipoic acid totally reversed toxin-evoked suppression of choline acetyltrasferase and pyruvate dehydrogenase activities, as well as mitochondrial and cytoplasmic acetyl-CoA levels, and partially attenuated increase of cell mortality. Significant negative correlations were found between enzyme activities, acetyl-CoA levels and cell mortality in different neurotoxic and neuroprotective conditions employed here. The level of cytoplamic acetyl-CoA correlated with mitochondrial acetyl-CoA, whereas choline acetyltransferase activity followed shifts in cytoplasmic acetyl-CoA. Thus, we conclude that, in cholinergic neurons, particular elements of the pyruvate–acetyl-CoA–acetylcholine pathway form a functional unit responding uniformly to nerotoxic and neuroprotectory conditions." @default.
• W2076059045 created "2016-06-24" @default.
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• W2076059045 date "2006-08-01" @default.
• W2076059045 modified "2023-09-24" @default.
• W2076059045 title "RS-α-lipoic acid protects cholinergic cells against sodium nitroprusside and amyloid-β neurotoxicity through restoration of acetyl-CoA level" @default.
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• W2076059045 doi "https://doi.org/10.1111/j.1471-4159.2006.03966.x" @default.
• W2076059045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16787407" @default.
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