Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076069761> ?p ?o ?g. }
- W2076069761 endingPage "8187" @default.
- W2076069761 startingPage "8173" @default.
- W2076069761 abstract "The amplitude and shape of EPSC waveforms are thought to be important determinants of information processing and storage in the brain, yet relatively little is known about the origins of EPSC variability or how it affects synaptic signaling. We investigated the stochastic determinants of AMPA receptor-mediated EPSC variability at cerebellar mossy fiber–granule cell (MF-GC) connections by combining multiple-probability fluctuation analysis (MPFA) and deconvolution methods. The properties of MF connections with a single release site and the effects of the rapidly equilibrating competitive antagonist kynurenic acid on EPSCs suggest that receptors are not saturated by glutamate during a quantal event and that quanta sum linearly over a wide range of release probabilities. MPFA revealed an average of five vesicular release sites per MF-GC connection. Our results show that the time course of vesicular release is rapid (decay, τ = 75 μs) and independent of release probability, introducing little jitter in the shape or timing of the quantal component of the EPSC at physiological temperature. Moreover, the peak vesicular release rate per release site after an action potential (AP) (∼3 ms –1 ) is substantially higher than previously reported for central synapses. Interaction of amplitude fluctuations arising from quantal release and quantal size with the slower, low variability spillover-mediated current produce substantial variability in EPSC shape. Our simulations of MF-GC transmission suggest that quantal variability and transmitter spillover extend the voltage from which AP threshold can be crossed, improving reliability, and that fast vesicular release allows precise signaling across MF connections with heterogeneous weights." @default.
- W2076069761 created "2016-06-24" @default.
- W2076069761 creator A5011837676 @default.
- W2076069761 creator A5046367950 @default.
- W2076069761 creator A5052777502 @default.
- W2076069761 creator A5053537999 @default.
- W2076069761 creator A5068840164 @default.
- W2076069761 date "2005-09-07" @default.
- W2076069761 modified "2023-10-04" @default.
- W2076069761 title "Rapid Vesicular Release, Quantal Variability, and Spillover Contribute to the Precision and Reliability of Transmission at a Glomerular Synapse" @default.
- W2076069761 cites W1558862799 @default.
- W2076069761 cites W1560145588 @default.
- W2076069761 cites W1600474674 @default.
- W2076069761 cites W1642181682 @default.
- W2076069761 cites W1670909519 @default.
- W2076069761 cites W1784467576 @default.
- W2076069761 cites W1878069218 @default.
- W2076069761 cites W1878427780 @default.
- W2076069761 cites W1883557202 @default.
- W2076069761 cites W1964433270 @default.
- W2076069761 cites W1965893090 @default.
- W2076069761 cites W1982073244 @default.
- W2076069761 cites W1983245247 @default.
- W2076069761 cites W1983877900 @default.
- W2076069761 cites W1984606410 @default.
- W2076069761 cites W1992219804 @default.
- W2076069761 cites W1995254751 @default.
- W2076069761 cites W2002426597 @default.
- W2076069761 cites W2010905290 @default.
- W2076069761 cites W2013427111 @default.
- W2076069761 cites W2013902743 @default.
- W2076069761 cites W2021194790 @default.
- W2076069761 cites W2023459285 @default.
- W2076069761 cites W2023654689 @default.
- W2076069761 cites W2027565428 @default.
- W2076069761 cites W2028226828 @default.
- W2076069761 cites W2028789389 @default.
- W2076069761 cites W2029732186 @default.
- W2076069761 cites W2036402923 @default.
- W2076069761 cites W2049181052 @default.
- W2076069761 cites W2052202414 @default.
- W2076069761 cites W2062234159 @default.
- W2076069761 cites W2063812162 @default.
- W2076069761 cites W2068435366 @default.
- W2076069761 cites W2069362932 @default.
- W2076069761 cites W2074728660 @default.
- W2076069761 cites W2075437459 @default.
- W2076069761 cites W2079428986 @default.
- W2076069761 cites W2085983301 @default.
- W2076069761 cites W2087758815 @default.
- W2076069761 cites W2089184936 @default.
- W2076069761 cites W2089764173 @default.
- W2076069761 cites W2093006120 @default.
- W2076069761 cites W2093550903 @default.
- W2076069761 cites W2094930349 @default.
- W2076069761 cites W2099736446 @default.
- W2076069761 cites W2100056505 @default.
- W2076069761 cites W2103048971 @default.
- W2076069761 cites W2104801499 @default.
- W2076069761 cites W2108791869 @default.
- W2076069761 cites W2109251081 @default.
- W2076069761 cites W2112685610 @default.
- W2076069761 cites W2112927743 @default.
- W2076069761 cites W2113832930 @default.
- W2076069761 cites W2118271804 @default.
- W2076069761 cites W2122383890 @default.
- W2076069761 cites W2131338541 @default.
- W2076069761 cites W2131844980 @default.
- W2076069761 cites W2133673540 @default.
- W2076069761 cites W2139621297 @default.
- W2076069761 cites W2142604892 @default.
- W2076069761 cites W2146381819 @default.
- W2076069761 cites W2153499119 @default.
- W2076069761 cites W2157860014 @default.
- W2076069761 cites W2163618989 @default.
- W2076069761 cites W2168194574 @default.
- W2076069761 cites W2170612760 @default.
- W2076069761 cites W4245552230 @default.
- W2076069761 cites W66833575 @default.
- W2076069761 doi "https://doi.org/10.1523/jneurosci.2051-05.2005" @default.
- W2076069761 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6725539" @default.
- W2076069761 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16148225" @default.
- W2076069761 hasPublicationYear "2005" @default.
- W2076069761 type Work @default.
- W2076069761 sameAs 2076069761 @default.
- W2076069761 citedByCount "87" @default.
- W2076069761 countsByYear W20760697612012 @default.
- W2076069761 countsByYear W20760697612013 @default.
- W2076069761 countsByYear W20760697612014 @default.
- W2076069761 countsByYear W20760697612015 @default.
- W2076069761 countsByYear W20760697612016 @default.
- W2076069761 countsByYear W20760697612017 @default.
- W2076069761 countsByYear W20760697612018 @default.
- W2076069761 countsByYear W20760697612019 @default.
- W2076069761 countsByYear W20760697612020 @default.
- W2076069761 countsByYear W20760697612021 @default.
- W2076069761 countsByYear W20760697612022 @default.
- W2076069761 countsByYear W20760697612023 @default.