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- W2076070160 abstract "The inactivation of rat atrial natriuretic factor (ANF) was studied using a bioassay, ANF-stimulated guanylate cyclase activity. Rat kidney membranes degraded ANF into biologically inactive forms. The primary cleavage site appears to be the Cys105-Phe106 bond. The degradation, measured by HPLC, followed classical Michaelis-Menten kinetics. The sensitivity of the enzyme to inhibitors suggested it to be a metalloendopeptidase, resembling neutral endopeptidase 24.11. When this enzyme, characterised by its enkephalin-degrading activity, was compared to the enzyme responsible for ANF inactivation, striking differences were found in tissue distribution, pH-dependence and sensitivity to protein-modifying reagents. It is concluded that an enzyme similar to endopeptidase 24.11 may be responsible for inactivation of atrial peptides in the rat." @default.
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- W2076070160 date "1988-10-01" @default.
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- W2076070160 title "Degradation of atrial natriuretic peptides by an enzyme in rat kidney resembling neutral endopeptidase 24.11" @default.
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- W2076070160 doi "https://doi.org/10.1016/0006-2952(88)90061-5" @default.
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