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- W2076085148 abstract "Normotensive women with a previous history of oestrogen-associated hypertension were found to have raised platelet factor 3 (PF3) availability, raised triglycerides and pre-beta-lipoprotein and impaired fibrinolytic activity and capacity, but were shown to have normal platelet lifespan and renal platelet localization. The significance of these abnormalities in relation to the development of hypertension and to the intrarenal vascular disease found in these patients is discussed.A study was undertaken to ascertain whether the intra-renal disease in estrogen-associated hypertension results from abnormalities of platelet function and/or fibrinolytic activity. 18 women, all of whom were normotensive before taking estrogen-containing OCs (oral contraceptives) and all of whom developed hypertension while taking OCs, were studied. They were compared with 23 healthy normotensive women who had never taken OCs. The women in the study group were found to have raised PF3 (platelet factor 3) availability, raised triglycerides and pre-beta-lipoprotein, and impaired fibrinolytic activity and capacity. The women, however, were found to have normal platelet lifespan and renal platelet localization. It is not possible, as a result of the study, to say whether these changes in fibrinolytic activity occurred as a result of estrogen therapy or whether they were actually present before the introduction of the estrogen. It is also not known whether these fibrinolytic changes indicate similar disturbances of intrarenal fibrinolytic activity. It is possible that estrogens can mediate vascular damage through either direct of indirect mechanisms." @default.
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- W2076085148 date "1980-08-01" @default.
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- W2076085148 title "PERSISTENT ABNORMALITIES OF FIBRINOLYTIC ACTIVITY AND PLATELET FUNCTION IN PATIENTS WITH REVERSIBLE OESTROGEN-ASSOCIATED HYPERTENSION" @default.
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- W2076085148 doi "https://doi.org/10.1111/j.1471-0528.1980.tb04600.x" @default.
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