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- W2076095673 abstract "Summary We have investigated the role of the R ho/ ROCK signaling pathway in the interaction of metastatic melanoma cells with the brain endothelium. ROCK inhibition induced a shift of melanoma cells to the mesenchymal phenotype, increased the number of melanoma cells attached to the brain endothelium, and strengthened the adhesion force between melanoma and endothelial cells. Inhibition of ROCK raised the number of melanoma cells migrating through the brain endothelial monolayer and promoted the formation of parenchymal brain metastases in vivo. We have shown that inhibition of the Rho/ ROCK pathway in melanoma, but not in brain endothelial cells, is responsible for this phenomenon. Our results indicate that the mesenchymal type of tumor cell movement is primordial in the transmigration of melanoma cells through the blood–brain barrier." @default.
- W2076095673 created "2016-06-24" @default.
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- W2076095673 date "2013-10-23" @default.
- W2076095673 modified "2023-10-16" @default.
- W2076095673 title "Role of Rho/<scp>ROCK</scp> signaling in the interaction of melanoma cells with the blood–brain barrier" @default.
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- W2076095673 doi "https://doi.org/10.1111/pcmr.12169" @default.
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