Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076095767> ?p ?o ?g. }
- W2076095767 endingPage "1289" @default.
- W2076095767 startingPage "1283" @default.
- W2076095767 abstract "Mineralocorticoids stimulate electrogenic Na+ transport in tight epithelia by altering the transcription of specific genes. Although the earliest mineralocorticoid effect is to increase the activity of the epithelial sodium channel (ENaC), ENaC mRNA and protein levels do not change. Instead, physiologic observations suggest that a mineralocorticoid target gene(s) encodes an ENaC regulator(s). To begin to identify and characterize mineralocorticoid-regulated target genes, we used suppression-subtractive hybridization to generate a cDNA library from A6 cells, a stable cell line of Xenopus laevis of distal nephron origin. A serine-threonine kinase, SGK, was identified from this screen. Sequence comparison revealed that frog, rat, and human SGK are 92% identical and 96% similar at the amino acid level. SGK mRNA was confirmed by Northern blot to be strongly and rapidly corticosteroid stimulated in A6 cells. In situ hybridization revealed that SGK was strongly stimulated by aldosterone in rat collecting duct but not proximal tubule cells. Low levels of SGK were present in rat glomeruli, but SGK was unregulated in this structure. Finally, SGK stimulated ENaC activity approximately sevenfold when coexpressed in Xenopus laevis oocytes. These data suggest that SGK is an important mediator of aldosterone effects on Na+ transport in tight epithelia. In view of the existence of SGK homologues in invertebrates, it is interesting to speculate that SGK is an ancient kinase that was adapted to the control of epithelial Na+ transport by early vertebrates as they made the transition from a marine to a freshwater environment." @default.
- W2076095767 created "2016-06-24" @default.
- W2076095767 creator A5015311189 @default.
- W2076095767 creator A5018369542 @default.
- W2076095767 creator A5030158673 @default.
- W2076095767 creator A5032764121 @default.
- W2076095767 creator A5042576322 @default.
- W2076095767 creator A5045828654 @default.
- W2076095767 creator A5074500898 @default.
- W2076095767 date "2000-04-01" @default.
- W2076095767 modified "2023-09-26" @default.
- W2076095767 title "Role of SGK in mineralocorticoid-regulated sodium transport" @default.
- W2076095767 cites W1615328259 @default.
- W2076095767 cites W1841050729 @default.
- W2076095767 cites W1973706463 @default.
- W2076095767 cites W1977518774 @default.
- W2076095767 cites W1990183776 @default.
- W2076095767 cites W1991468122 @default.
- W2076095767 cites W1997986332 @default.
- W2076095767 cites W1999163644 @default.
- W2076095767 cites W2002521426 @default.
- W2076095767 cites W2004250443 @default.
- W2076095767 cites W2010733391 @default.
- W2076095767 cites W2012617920 @default.
- W2076095767 cites W2017255096 @default.
- W2076095767 cites W2020653967 @default.
- W2076095767 cites W2057209958 @default.
- W2076095767 cites W2059041510 @default.
- W2076095767 cites W2060300669 @default.
- W2076095767 cites W2076629036 @default.
- W2076095767 cites W2082181748 @default.
- W2076095767 cites W2084916914 @default.
- W2076095767 cites W2111073757 @default.
- W2076095767 cites W2120245762 @default.
- W2076095767 cites W2136061619 @default.
- W2076095767 cites W2148114970 @default.
- W2076095767 cites W2169494292 @default.
- W2076095767 cites W2314848953 @default.
- W2076095767 cites W2405102669 @default.
- W2076095767 cites W4246606395 @default.
- W2076095767 doi "https://doi.org/10.1046/j.1523-1755.2000.00963.x" @default.
- W2076095767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10760055" @default.
- W2076095767 hasPublicationYear "2000" @default.
- W2076095767 type Work @default.
- W2076095767 sameAs 2076095767 @default.
- W2076095767 citedByCount "59" @default.
- W2076095767 countsByYear W20760957672012 @default.
- W2076095767 countsByYear W20760957672013 @default.
- W2076095767 countsByYear W20760957672014 @default.
- W2076095767 countsByYear W20760957672015 @default.
- W2076095767 countsByYear W20760957672016 @default.
- W2076095767 countsByYear W20760957672019 @default.
- W2076095767 countsByYear W20760957672022 @default.
- W2076095767 crossrefType "journal-article" @default.
- W2076095767 hasAuthorship W2076095767A5015311189 @default.
- W2076095767 hasAuthorship W2076095767A5018369542 @default.
- W2076095767 hasAuthorship W2076095767A5030158673 @default.
- W2076095767 hasAuthorship W2076095767A5032764121 @default.
- W2076095767 hasAuthorship W2076095767A5042576322 @default.
- W2076095767 hasAuthorship W2076095767A5045828654 @default.
- W2076095767 hasAuthorship W2076095767A5074500898 @default.
- W2076095767 hasBestOaLocation W20760957671 @default.
- W2076095767 hasConcept C104317684 @default.
- W2076095767 hasConcept C126322002 @default.
- W2076095767 hasConcept C134018914 @default.
- W2076095767 hasConcept C153911025 @default.
- W2076095767 hasConcept C178790620 @default.
- W2076095767 hasConcept C185592680 @default.
- W2076095767 hasConcept C189135053 @default.
- W2076095767 hasConcept C2776069600 @default.
- W2076095767 hasConcept C2778525890 @default.
- W2076095767 hasConcept C2779535977 @default.
- W2076095767 hasConcept C537181965 @default.
- W2076095767 hasConcept C55493867 @default.
- W2076095767 hasConcept C6507245 @default.
- W2076095767 hasConcept C71924100 @default.
- W2076095767 hasConcept C86803240 @default.
- W2076095767 hasConcept C95444343 @default.
- W2076095767 hasConceptScore W2076095767C104317684 @default.
- W2076095767 hasConceptScore W2076095767C126322002 @default.
- W2076095767 hasConceptScore W2076095767C134018914 @default.
- W2076095767 hasConceptScore W2076095767C153911025 @default.
- W2076095767 hasConceptScore W2076095767C178790620 @default.
- W2076095767 hasConceptScore W2076095767C185592680 @default.
- W2076095767 hasConceptScore W2076095767C189135053 @default.
- W2076095767 hasConceptScore W2076095767C2776069600 @default.
- W2076095767 hasConceptScore W2076095767C2778525890 @default.
- W2076095767 hasConceptScore W2076095767C2779535977 @default.
- W2076095767 hasConceptScore W2076095767C537181965 @default.
- W2076095767 hasConceptScore W2076095767C55493867 @default.
- W2076095767 hasConceptScore W2076095767C6507245 @default.
- W2076095767 hasConceptScore W2076095767C71924100 @default.
- W2076095767 hasConceptScore W2076095767C86803240 @default.
- W2076095767 hasConceptScore W2076095767C95444343 @default.
- W2076095767 hasIssue "4" @default.
- W2076095767 hasLocation W20760957671 @default.
- W2076095767 hasLocation W20760957672 @default.
- W2076095767 hasOpenAccess W2076095767 @default.