FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076100769> ?p ?o ?g. }

• W2076100769 endingPage "1894" @default.
• W2076100769 startingPage "1894" @default.
• W2076100769 abstract "We used ¹⁸F-dopa PET to examine concordance for dysfunction of the nigrostriatal dopaminergic system in 18 co-twins of patients with Parkinson9s disease (PD) and scanned one clinically concordant monozygotic (MZ) twin pair, 17 asymptomatic co-twins (10 MZ, 7 dizygotic [DZ]), and 13 twins with PD (8 MZ, 5 DZ). Mean ¹⁸F-dopa uptake of the twins with PD was significantly reduced in putamen to 38% and in caudate to 66% of normal. Mean putamen ¹⁸F-dopa uptake for the 17 asymptomatic co-twins was also significantly reduced (86% of normal), as was putamen tracer uptake for the 10 MZ (87% of normal) and seven DZ (83% of normal) asymptomatic co-twin subgroups. Four of 10 MZ and two of seven DZ asymptomatic co-twins had putamen ¹⁸F-dopa uptake reduced more than 2 SDs below the normal mean. Three of these four asymptomatic MZ co-twins had tremor on examination at the time of PET and one has now developed PD 2 years later. Our PET findings give concordances for nigral dysfunction of 45% in the MZ pairs and 29% in the DZ pairs at a 2-SD threshold, and 18% in MZ and 0% in DZ pairs at a 3-SD threshold of significance. These data suggest that the concordance for nigral pathology in PD twins may be higher than previously realized and that the presence of an isolated postural or rest tremor may be a phenotypic expression of PD." @default.
• W2076100769 created "2016-06-24" @default.
• W2076100769 creator A5001790598 @default.
• W2076100769 creator A5020688139 @default.
• W2076100769 creator A5027031337 @default.
• W2076100769 creator A5036018066 @default.
• W2076100769 creator A5043554245 @default.
• W2076100769 creator A5045336469 @default.
• W2076100769 creator A5071867646 @default.
• W2076100769 creator A5076510878 @default.
• W2076100769 creator A5085983497 @default.
• W2076100769 date "1992-10-01" @default.
• W2076100769 modified "2023-09-23" @default.
• W2076100769 title "Parkinson's disease in twins studied with 18F-dopa and positron emission tomography" @default.
• W2076100769 doi "https://doi.org/10.1212/wnl.42.10.1894" @default.
• W2076100769 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1407569" @default.
• W2076100769 hasPublicationYear "1992" @default.
• W2076100769 type Work @default.
• W2076100769 sameAs 2076100769 @default.
• W2076100769 citedByCount "191" @default.
• W2076100769 countsByYear W20761007692012 @default.
• W2076100769 countsByYear W20761007692014 @default.
• W2076100769 countsByYear W20761007692015 @default.
• W2076100769 countsByYear W20761007692016 @default.
• W2076100769 countsByYear W20761007692017 @default.
• W2076100769 countsByYear W20761007692018 @default.
• W2076100769 countsByYear W20761007692019 @default.
• W2076100769 countsByYear W20761007692020 @default.
• W2076100769 countsByYear W20761007692021 @default.
• W2076100769 countsByYear W20761007692022 @default.
• W2076100769 countsByYear W20761007692023 @default.
• W2076100769 crossrefType "journal-article" @default.
• W2076100769 hasAuthorship W2076100769A5001790598 @default.
• W2076100769 hasAuthorship W2076100769A5020688139 @default.
• W2076100769 hasAuthorship W2076100769A5027031337 @default.
• W2076100769 hasAuthorship W2076100769A5036018066 @default.
• W2076100769 hasAuthorship W2076100769A5043554245 @default.
• W2076100769 hasAuthorship W2076100769A5045336469 @default.
• W2076100769 hasAuthorship W2076100769A5071867646 @default.
• W2076100769 hasAuthorship W2076100769A5076510878 @default.
• W2076100769 hasAuthorship W2076100769A5085983497 @default.
• W2076100769 hasConcept C126322002 @default.
• W2076100769 hasConcept C137916694 @default.
• W2076100769 hasConcept C160798450 @default.
• W2076100769 hasConcept C2777910003 @default.
• W2076100769 hasConcept C2779134260 @default.
• W2076100769 hasConcept C2779714222 @default.
• W2076100769 hasConcept C2779734285 @default.
• W2076100769 hasConcept C2989005 @default.
• W2076100769 hasConcept C3017743773 @default.
• W2076100769 hasConcept C54355233 @default.
• W2076100769 hasConcept C71924100 @default.
• W2076100769 hasConcept C86803240 @default.
• W2076100769 hasConceptScore W2076100769C126322002 @default.
• W2076100769 hasConceptScore W2076100769C137916694 @default.
• W2076100769 hasConceptScore W2076100769C160798450 @default.
• W2076100769 hasConceptScore W2076100769C2777910003 @default.
• W2076100769 hasConceptScore W2076100769C2779134260 @default.
• W2076100769 hasConceptScore W2076100769C2779714222 @default.
• W2076100769 hasConceptScore W2076100769C2779734285 @default.
• W2076100769 hasConceptScore W2076100769C2989005 @default.
• W2076100769 hasConceptScore W2076100769C3017743773 @default.
• W2076100769 hasConceptScore W2076100769C54355233 @default.
• W2076100769 hasConceptScore W2076100769C71924100 @default.
• W2076100769 hasConceptScore W2076100769C86803240 @default.
• W2076100769 hasIssue "10" @default.
• W2076100769 hasLocation W20761007691 @default.
• W2076100769 hasLocation W20761007692 @default.
• W2076100769 hasOpenAccess W2076100769 @default.
• W2076100769 hasPrimaryLocation W20761007691 @default.
• W2076100769 hasRelatedWork W1987215768 @default.
• W2076100769 hasRelatedWork W1991129960 @default.
• W2076100769 hasRelatedWork W1995188757 @default.
• W2076100769 hasRelatedWork W2016679923 @default.
• W2076100769 hasRelatedWork W2076100769 @default.
• W2076100769 hasRelatedWork W2116001782 @default.
• W2076100769 hasRelatedWork W3191129679 @default.
• W2076100769 hasRelatedWork W4229900919 @default.
• W2076100769 hasRelatedWork W4306659007 @default.
• W2076100769 hasRelatedWork W17604275 @default.
• W2076100769 hasVolume "42" @default.
• W2076100769 isParatext "false" @default.
• W2076100769 isRetracted "false" @default.
• W2076100769 magId "2076100769" @default.
• W2076100769 workType "article" @default.