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• W2076102443 abstract "Mouse peritoneal macrophages (MPM) elicited by paraffin oil (PO) or thioglycollate (TG) were compared in their capacity to generate oxidative burst (OB) products such as superoxide ion (O2−) and hydrogen peroxide (H2O2) and lyse target erythrocytes. Strong OB stimulants such as 12-O-tetradecanoyl-phorbol-13-acetate (TPA), opsonized zymosan, and wheat-germ agglutinin (WGA) were found to stimulate O2− and H2O2 production by both PO- and TG-elicited MPM. PO-elicited MPM exhibited a vigorous OB response compared to TG-elicited MPM and showed a higher degree of self iodination in the presence of 125I. Macrophage-mediated cytolysis of 51Cr-labeled red blood cells, following OB stimulation, was revealed by PO-elicited MPM triggered by TPA, opsonized zymosan, WGA, and Concanavalin A. TG-elicited MPM failed to respond to TPA and opsonized zymosan. In the presence of horseradish peroxidase, both PO- and TG-elicited MPM exhibited augmented cytocidal activities upon stimulation with TPA, whereas catalase abrogated the capacity of TPA-stimulated MPM to lyse red blood cells, which may suggest the involvement of H2O2 in the lytic process." @default.
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• W2076102443 date "1983-07-01" @default.
• W2076102443 modified "2023-09-26" @default.
• W2076102443 title "The Oxidative Burst and Related Phenomena in Mouse Macrophages Elicited by Different Sterile Inflammatory Stimuli" @default.
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• W2076102443 doi "https://doi.org/10.1016/s0171-2985(83)80048-5" @default.
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