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• W2076103145 abstract "It has been shown that following peripheral nerve injury brain-derived neurotrophic factor (BDNF) released by activated microglia contributes to neuropathic pain, but whether BDNF affects the function of microglia is still unknown. In the present work we found that spinal application of BDNF, which induced long-term potentiation (LTP) of C-fiber evoked field potentials, activated spinal microglia in naïve animals, while pretreatment with microglia inhibitor minocycline blocked BDNF-induced LTP. In addition, following LTP induction by BDNF, both phosphorylated Src-family kinases (p-SFKs) and phosphorylated p38 mitogen-activated protein kinase (p-p38 MAPK) were up-regulated only in spinal microglia but not in neurons and astrocytes, whilst spinal application of SFKs inhibitor (PP2 or SU6656) or p38 MAPK inhibitor (SB203580) blocked BDNF-induced LTP and suppressed microglial activation. As spinal LTP at C-fiber synapses is considered to underlie neuropathic pain, we subsequently examined whether BDNF may contribute to mechanical hypersensitivity by activation of spinal microglia using spared nerve injury (SNI) model. Following SNI BDNF and TrkB receptor were up-regulated mainly in dorsal horn neurons and in activated microglia, and p-SFKs and p-p38 MAPK were increased exclusively in microglia. Intrathecal injection of BDNF scavenger TrkB-Fc starting before SNI, which prevented the behavioral sign of neuropathic pain, suppressed both microglial activation and the up-regulation of p-SFKs and p-p38 MAPK produced by SNI. Thus, the increased BDNF/TrkB signaling in spinal dorsal horn may contribute to neuropathic pain by activation of microglia following peripheral nerve injury and inhibition of SFKs or p38 MAPK may selectively inhibit microglia in spinal dorsal horn." @default.
• W2076103145 created "2016-06-24" @default.
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• W2076103145 date "2011-02-01" @default.
• W2076103145 modified "2023-10-18" @default.
• W2076103145 title "Brain-derived neurotrophic factor contributes to spinal long-term potentiation and mechanical hypersensitivity by activation of spinal microglia in rat" @default.
• W2076103145 cites W1568010017 @default.
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• W2076103145 cites W1766369466 @default.
• W2076103145 cites W1841237986 @default.
• W2076103145 cites W1964186052 @default.
• W2076103145 cites W1966628027 @default.
• W2076103145 cites W1978052983 @default.
• W2076103145 cites W1979675387 @default.
• W2076103145 cites W1982942262 @default.
• W2076103145 cites W1985763589 @default.
• W2076103145 cites W1988006913 @default.
• W2076103145 cites W1988889092 @default.
• W2076103145 cites W1994523411 @default.
• W2076103145 cites W2006403823 @default.
• W2076103145 cites W2006680088 @default.
• W2076103145 cites W2010791222 @default.
• W2076103145 cites W2017753442 @default.
• W2076103145 cites W2022810647 @default.
• W2076103145 cites W2023830878 @default.
• W2076103145 cites W2025388917 @default.
• W2076103145 cites W2028475553 @default.
• W2076103145 cites W2030076800 @default.
• W2076103145 cites W2031736836 @default.
• W2076103145 cites W2032280503 @default.
• W2076103145 cites W2033852830 @default.
• W2076103145 cites W2037919084 @default.
• W2076103145 cites W2038381968 @default.
• W2076103145 cites W2038702076 @default.
• W2076103145 cites W2038839265 @default.
• W2076103145 cites W2041562559 @default.
• W2076103145 cites W2043946280 @default.
• W2076103145 cites W2046404343 @default.
• W2076103145 cites W2047010161 @default.
• W2076103145 cites W2050181320 @default.
• W2076103145 cites W2054595326 @default.
• W2076103145 cites W2056688527 @default.
• W2076103145 cites W2063153146 @default.
• W2076103145 cites W2066796908 @default.
• W2076103145 cites W2067761092 @default.
• W2076103145 cites W2077680393 @default.
• W2076103145 cites W2079472132 @default.
• W2076103145 cites W2079840847 @default.
• W2076103145 cites W2083560398 @default.
• W2076103145 cites W2086866828 @default.
• W2076103145 cites W2087454739 @default.
• W2076103145 cites W2090863733 @default.
• W2076103145 cites W2091057535 @default.
• W2076103145 cites W2093522308 @default.
• W2076103145 cites W2094584128 @default.
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• W2076103145 cites W2114793539 @default.
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• W2076103145 cites W2128994172 @default.
• W2076103145 cites W2129672972 @default.
• W2076103145 cites W2132573038 @default.
• W2076103145 cites W2133316133 @default.
• W2076103145 cites W2134730303 @default.
• W2076103145 cites W2135247591 @default.
• W2076103145 cites W2137979524 @default.
• W2076103145 cites W2140193821 @default.
• W2076103145 cites W2140441724 @default.
• W2076103145 cites W2140921695 @default.
• W2076103145 cites W2143210066 @default.
• W2076103145 cites W2154684087 @default.
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• W2076103145 cites W2162730620 @default.
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• W2076103145 doi "https://doi.org/10.1016/j.bbi.2010.09.025" @default.
• W2076103145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20933591" @default.
• W2076103145 hasPublicationYear "2011" @default.
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