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- W2076103624 abstract "Background: The prevalence of HIV primary resistance mutations has increased overtime and transmitted mutations can persist in HIV-1 chronically infected patients. Studies have shown that it is cost-effective to perform primary resistance testing when one observes a prevalence of HIV-1 primary resistance above 5% in a certain geographical location. Nevertheless, such studies were conducted among acutely/recent HIV infected patients. Our study hypothesis was that HIV-1 primary resistance prevalence would be greater than 5% among HIV-1 chronically infected patients with indication for antiretroviral therapy in Brazil's Southeast (SE) region. Methods: We have included 75 patients from 2 major cities: 47 from Rio de Janeiro and 28 from Santos. Our population profile was non-pregnant chronically HIV-1 infected patients with indication for antiretroviral therapy based on National Guidelines. HIV DNA was extracted and amplified from dried blood spots samples. HIV's pol gene protease and reverse transcriptase regions were sequenced. Antiretroviral resistance mutations algorithm which excludes frequent polymorphisms was utilized. Results: Prevalence of HIV-1 primary resistance was 17,3%. 18 mutations were observed among 13 out of 75 included patients. Of these 18 mutations, 10 were related with NRTI's, 8 were related to NNRTI's and none to PI's. The most commonly detected mutations were: K103N (16.6%), T69D (11.1%), M41L (11.1%). Only 4% (3 individuals) had two class (NRTI and NNRTI) primary resistance mutations. The most prevalent HIV subtype was B (77.3%), followed by BF (33.3%), F (6.66%) and C (1.3%). Conclusion: High primary resistance levels were observed according to WHO's definition (5–15%), suggesting being cost-effective to perform primary resistance testing in this region. The increased prevalence of NNRTI's mutations and the absence of M184V mutations are two findings observed in this study, contrasting with previous studies from Brazil. Abstracts for SupplementInternational Journal of Infectious DiseasesVol. 14Preview Full-Text PDF Open Archive" @default.
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- W2076103624 date "2010-03-01" @default.
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- W2076103624 title "Prevalence of HIV-1 primary resistance among HIV chronically infected patients in Brazil's Southeast region" @default.
- W2076103624 doi "https://doi.org/10.1016/j.ijid.2010.02.2035" @default.
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