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- W2076103687 abstract "Over the 20-min period following exposure of young chicks to a flashing light as an imprinting stimulus there is an increased incorporation of [14C]leucine into an acidic (tubulin-enriched) protein fraction of the anterior dorsal forebrain in birds which have learnt the characteristics of the stimulus as compared with, either birds which have been exposed to an imprinting stimulus but learn poorly, or chicks kept in the dark. This brain region has been implicated in several studies as the locus for a number of biochemical modulations that accompany learning. The amount of [14C]leucine incorporated does not seem to be determined by precursor pool availability; it does, however, correlate with a well-validated measure of the extent to which birds have learnt to recognise the characteristics of the stimulus, as shown by a two-choice discrimination test. There is no change in the total content of tubulin dimer as assayed by colchicine binding under these conditions. Additionally, in birds which show evidence of learning, the binding of quinuclidinyl benzilate, an irreversible muscarinic ligand, is altered in both the posterior dorsal forebrain and midbrain regions. None of these effects could be simply the result of visual stimulation. The meaning of these changes is discussed." @default.
- W2076103687 created "2016-06-24" @default.
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- W2076103687 date "1981-11-01" @default.
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- W2076103687 title "Ontogenetic and Imprinting-Induced Changes in Chick Brain Protein Metabolism and Muscarinic Receptor Binding Activity" @default.
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- W2076103687 doi "https://doi.org/10.1111/j.1471-4159.1981.tb04658.x" @default.
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