FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076115718> ?p ?o ?g. }

• W2076115718 endingPage "199" @default.
• W2076115718 startingPage "191" @default.
• W2076115718 abstract "Parathyroid hormone-related protein (PTHrP) contains a nuclear localization signal (NLS) sequence within 87-107. NLS sequences are generally capable of penetrating cellular membranes due to a richness of basic amino acid residues, and thus have been used as cell-penetrating peptides (CPPs) to translocate biologically active peptides/proteins into cells. The NLS sequence of PTHrP is not exception to this finding; however, PTHrP(87-107) contains 2 acidic glutamate residues at 99 and 101 within the basic amino acid stretch, which is not commonly observed in other CPPs such as HIV-1 Tat(48-60). In this study, we indicated structure-function relationship of the PTHrP NLS to understand the effect of acidic glutamate residues on cell permeability and intracellular localization. We chemically synthesized PTHrP(87-107) and its N-terminally truncated analogues. Their intracellular localization pattern was analyzed by microscopy, radioimmunoassay, and fluorescence-activated cell sorting. Although all analogues were translocated into cells, internalization by the cytoplasm and/or nucleus was length-dependent; specifically, PTHrP(97-107), PTHrP(95-107), and PTHrP(93-107) were more frequently localized in the cytoplasm. We assume that reduction in the net positive charge within PTHrP NLS analogues resulted in increased cytoplasm- translocation activity. We propose that PTHrP(97-107) is a useful carrier peptide for delivery and expression of cargo molecules in the cytoplasm." @default.
• W2076115718 created "2016-06-24" @default.
• W2076115718 creator A5006506867 @default.
• W2076115718 creator A5050707431 @default.
• W2076115718 creator A5056477341 @default.
• W2076115718 creator A5067299967 @default.
• W2076115718 creator A5069349112 @default.
• W2076115718 creator A5073523634 @default.
• W2076115718 creator A5077384482 @default.
• W2076115718 creator A5078818800 @default.
• W2076115718 date "2012-01-01" @default.
• W2076115718 modified "2023-09-28" @default.
• W2076115718 title "Structure-function relationship of the nuclear localization signal sequence of parathyroid hormone-related protein" @default.
• W2076115718 cites W1584683177 @default.
• W2076115718 cites W1968327678 @default.
• W2076115718 cites W1978314610 @default.
• W2076115718 cites W1990806106 @default.
• W2076115718 cites W1992230504 @default.
• W2076115718 cites W2003961223 @default.
• W2076115718 cites W2007783940 @default.
• W2076115718 cites W2017211434 @default.
• W2076115718 cites W2019889336 @default.
• W2076115718 cites W2020814497 @default.
• W2076115718 cites W2028357660 @default.
• W2076115718 cites W2029346749 @default.
• W2076115718 cites W2034419606 @default.
• W2076115718 cites W2035662242 @default.
• W2076115718 cites W2042143995 @default.
• W2076115718 cites W2045309657 @default.
• W2076115718 cites W2052706007 @default.
• W2076115718 cites W2072129936 @default.
• W2076115718 cites W2084255320 @default.
• W2076115718 cites W2085034745 @default.
• W2076115718 cites W2105668301 @default.
• W2076115718 cites W2112921922 @default.
• W2076115718 cites W2124001296 @default.
• W2076115718 cites W2132498623 @default.
• W2076115718 cites W2157031202 @default.
• W2076115718 cites W2160753380 @default.
• W2076115718 cites W4239028853 @default.
• W2076115718 doi "https://doi.org/10.2220/biomedres.33.191" @default.
• W2076115718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22790219" @default.
• W2076115718 hasPublicationYear "2012" @default.
• W2076115718 type Work @default.
• W2076115718 sameAs 2076115718 @default.
• W2076115718 citedByCount "6" @default.
• W2076115718 countsByYear W20761157182014 @default.
• W2076115718 countsByYear W20761157182019 @default.
• W2076115718 countsByYear W20761157182021 @default.
• W2076115718 countsByYear W20761157182022 @default.
• W2076115718 crossrefType "journal-article" @default.
• W2076115718 hasAuthorship W2076115718A5006506867 @default.
• W2076115718 hasAuthorship W2076115718A5050707431 @default.
• W2076115718 hasAuthorship W2076115718A5056477341 @default.
• W2076115718 hasAuthorship W2076115718A5067299967 @default.
• W2076115718 hasAuthorship W2076115718A5069349112 @default.
• W2076115718 hasAuthorship W2076115718A5073523634 @default.
• W2076115718 hasAuthorship W2076115718A5077384482 @default.
• W2076115718 hasAuthorship W2076115718A5078818800 @default.
• W2076115718 hasBestOaLocation W20761157181 @default.
• W2076115718 hasConcept C104317684 @default.
• W2076115718 hasConcept C12554922 @default.
• W2076115718 hasConcept C139770010 @default.
• W2076115718 hasConcept C1491633281 @default.
• W2076115718 hasConcept C167625842 @default.
• W2076115718 hasConcept C185592680 @default.
• W2076115718 hasConcept C186435350 @default.
• W2076115718 hasConcept C190062978 @default.
• W2076115718 hasConcept C49805395 @default.
• W2076115718 hasConcept C515207424 @default.
• W2076115718 hasConcept C55493867 @default.
• W2076115718 hasConcept C79879829 @default.
• W2076115718 hasConcept C86803240 @default.
• W2076115718 hasConcept C95444343 @default.
• W2076115718 hasConceptScore W2076115718C104317684 @default.
• W2076115718 hasConceptScore W2076115718C12554922 @default.
• W2076115718 hasConceptScore W2076115718C139770010 @default.
• W2076115718 hasConceptScore W2076115718C1491633281 @default.
• W2076115718 hasConceptScore W2076115718C167625842 @default.
• W2076115718 hasConceptScore W2076115718C185592680 @default.
• W2076115718 hasConceptScore W2076115718C186435350 @default.
• W2076115718 hasConceptScore W2076115718C190062978 @default.
• W2076115718 hasConceptScore W2076115718C49805395 @default.
• W2076115718 hasConceptScore W2076115718C515207424 @default.
• W2076115718 hasConceptScore W2076115718C55493867 @default.
• W2076115718 hasConceptScore W2076115718C79879829 @default.
• W2076115718 hasConceptScore W2076115718C86803240 @default.
• W2076115718 hasConceptScore W2076115718C95444343 @default.
• W2076115718 hasIssue "3" @default.
• W2076115718 hasLocation W20761157181 @default.
• W2076115718 hasLocation W20761157182 @default.
• W2076115718 hasOpenAccess W2076115718 @default.
• W2076115718 hasPrimaryLocation W20761157181 @default.
• W2076115718 hasRelatedWork W1940540375 @default.
• W2076115718 hasRelatedWork W1997843344 @default.
• W2076115718 hasRelatedWork W2003190738 @default.
• W2076115718 hasRelatedWork W2026314103 @default.
• W2076115718 hasRelatedWork W2042197077 @default.

• next