Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076116463> ?p ?o ?g. }
- W2076116463 endingPage "47" @default.
- W2076116463 startingPage "40" @default.
- W2076116463 abstract "To systematically review available evidence regarding whether second-generation antiepileptic drugs (AEDs) contribute to the risk of balance disorders.We systematically evaluated data from randomized controlled trials that compared adjunctive therapy with a second-generation AED (gabapentin, lamotrigine, levetiracetam, oxcarbazepine, pregabalin, tiagabine, topIramate, or zonisamide) vs placebo for partial epilepsy and that reported dose-specific rates of ataxia or Imbalance for each group. Random-effects meta-analysis was used to pool ratios (risk ratio [RR]) and associated 95% confidence Intervals to determine whether there was evidence of an overall AED class effect or a dose-response effect and whether there were differences between Individual AEDs.Sixteen studies met inclusion criteria, representing 4279 individuals randomized to a second-generation AED and 1830 patients to placebo. Pooled analyses of all AEDs demonstrated that they Increase imbalance risk at any dose (RR, 2.73; 95% confidence interval, 2.07-3.61) and at lowest dose (RR, 1.76; 95% confidence interval, 1.26-2.46). The highest dose analysis showed heterogeneity; evaluation of individual AEDs revealed that oxcarbamazepine and topiramate increased imbalance risk at all doses, whereas gabapentin and levetiracetam did not increase imbalance risk at any dose. A dose-response effect was observed for most AEDs.Second-generation AEDs at standard dosages, except for gabapentin and levetiracetam, increase the imbalance risk, and evidence exists for a dose-response effect. The mechanisms, risk factors, and consequences of this risk for individual AEDs warrant further study." @default.
- W2076116463 created "2016-06-24" @default.
- W2076116463 creator A5008002660 @default.
- W2076116463 creator A5030010442 @default.
- W2076116463 creator A5080537406 @default.
- W2076116463 creator A5088021264 @default.
- W2076116463 date "2007-01-01" @default.
- W2076116463 modified "2023-09-30" @default.
- W2076116463 title "Second-Generation Antiepileptic Drugs' Impact on Balance: A Meta-analysis" @default.
- W2076116463 cites W1968217355 @default.
- W2076116463 cites W1974098973 @default.
- W2076116463 cites W1976810263 @default.
- W2076116463 cites W1979558709 @default.
- W2076116463 cites W1981581965 @default.
- W2076116463 cites W1989340210 @default.
- W2076116463 cites W1995716893 @default.
- W2076116463 cites W2000015972 @default.
- W2076116463 cites W2006821779 @default.
- W2076116463 cites W2020996076 @default.
- W2076116463 cites W2022532249 @default.
- W2076116463 cites W2025490080 @default.
- W2076116463 cites W2033830039 @default.
- W2076116463 cites W2038656059 @default.
- W2076116463 cites W2040099731 @default.
- W2076116463 cites W2041426021 @default.
- W2076116463 cites W2043242122 @default.
- W2076116463 cites W2051597408 @default.
- W2076116463 cites W2059212626 @default.
- W2076116463 cites W2060417951 @default.
- W2076116463 cites W2065174084 @default.
- W2076116463 cites W2070403944 @default.
- W2076116463 cites W2078797427 @default.
- W2076116463 cites W2080494081 @default.
- W2076116463 cites W2088002520 @default.
- W2076116463 cites W2092254107 @default.
- W2076116463 cites W2094074893 @default.
- W2076116463 cites W2095383648 @default.
- W2076116463 cites W2099686832 @default.
- W2076116463 cites W2117449343 @default.
- W2076116463 cites W2129745199 @default.
- W2076116463 cites W2131150621 @default.
- W2076116463 cites W2165273174 @default.
- W2076116463 cites W2166477860 @default.
- W2076116463 cites W2168143783 @default.
- W2076116463 cites W2171332093 @default.
- W2076116463 cites W2300163045 @default.
- W2076116463 cites W4234152066 @default.
- W2076116463 cites W4235731737 @default.
- W2076116463 cites W4247231670 @default.
- W2076116463 cites W4253837878 @default.
- W2076116463 cites W6801438 @default.
- W2076116463 doi "https://doi.org/10.4065/82.1.40" @default.
- W2076116463 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17285784" @default.
- W2076116463 hasPublicationYear "2007" @default.
- W2076116463 type Work @default.
- W2076116463 sameAs 2076116463 @default.
- W2076116463 citedByCount "16" @default.
- W2076116463 countsByYear W20761164632012 @default.
- W2076116463 countsByYear W20761164632014 @default.
- W2076116463 countsByYear W20761164632015 @default.
- W2076116463 countsByYear W20761164632017 @default.
- W2076116463 countsByYear W20761164632018 @default.
- W2076116463 countsByYear W20761164632021 @default.
- W2076116463 countsByYear W20761164632023 @default.
- W2076116463 crossrefType "journal-article" @default.
- W2076116463 hasAuthorship W2076116463A5008002660 @default.
- W2076116463 hasAuthorship W2076116463A5030010442 @default.
- W2076116463 hasAuthorship W2076116463A5080537406 @default.
- W2076116463 hasAuthorship W2076116463A5088021264 @default.
- W2076116463 hasConcept C118552586 @default.
- W2076116463 hasConcept C126322002 @default.
- W2076116463 hasConcept C142724271 @default.
- W2076116463 hasConcept C168563851 @default.
- W2076116463 hasConcept C204787440 @default.
- W2076116463 hasConcept C27081682 @default.
- W2076116463 hasConcept C2776468701 @default.
- W2076116463 hasConcept C2776608144 @default.
- W2076116463 hasConcept C2776749334 @default.
- W2076116463 hasConcept C2777138316 @default.
- W2076116463 hasConcept C2777332695 @default.
- W2076116463 hasConcept C2777683783 @default.
- W2076116463 hasConcept C2778186239 @default.
- W2076116463 hasConcept C2778802184 @default.
- W2076116463 hasConcept C2779253243 @default.
- W2076116463 hasConcept C2781176495 @default.
- W2076116463 hasConcept C42219234 @default.
- W2076116463 hasConcept C44249647 @default.
- W2076116463 hasConcept C71924100 @default.
- W2076116463 hasConcept C82789193 @default.
- W2076116463 hasConcept C95190672 @default.
- W2076116463 hasConceptScore W2076116463C118552586 @default.
- W2076116463 hasConceptScore W2076116463C126322002 @default.
- W2076116463 hasConceptScore W2076116463C142724271 @default.
- W2076116463 hasConceptScore W2076116463C168563851 @default.
- W2076116463 hasConceptScore W2076116463C204787440 @default.
- W2076116463 hasConceptScore W2076116463C27081682 @default.
- W2076116463 hasConceptScore W2076116463C2776468701 @default.
- W2076116463 hasConceptScore W2076116463C2776608144 @default.