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- W2076120046 abstract "The present paper describes a protective role of l ‐tyrosine against aggregation of caeruloplasmin and haemoglobin therapeutic proteins during their sterilization by γ‐irradiation in the aqueous phase. Irradiation of proteins, known to induce their degradation in the presence of oxygen, generates aggregation under oxygen‐free conditions. It was found that l ‐tyrosine present during irradiation in deoxygenated media prevents protein aggregation even at high doses (10 kGy), as asserted by SDS/PAGE and high‐performance size‐exclusion chromatography. The protective role of l ‐tyrosine, allowing the γ‐irradiation treatment of therapeutic proteins in solution without conformational alteration, is probably exerted by scavenging oxygen radicals produced by irradiation‐induced water radiolysis. It was also found that haemoglobin had a greater stability than caeruloplasmin under γ‐irradiation treatment." @default.
- W2076120046 created "2016-06-24" @default.
- W2076120046 creator A5029193003 @default.
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- W2076120046 date "2003-10-01" @default.
- W2076120046 modified "2023-10-16" @default.
- W2076120046 title "l-Tyrosine prevents aggregation of therapeutic proteins by γ-irradiation" @default.
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- W2076120046 doi "https://doi.org/10.1042/ba20030038" @default.
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