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• W2076121010 startingPage "952" @default.
• W2076121010 abstract "Peptide-major histocompatibility complex protein complexes (pMHCs) on antigen-presenting cells (APCs) are central to T cell activation. Within minutes of peptide-specific T cells interacting with APCs, pMHCs on APCs formed clusters at the site of T cell contact. Thereafter, these clusters were acquired by T cells and internalized through T cell receptor-mediated endocytosis. During this process, T cells became sensitive to peptide-specific lysis by neighboring T cells (fratricide). This form of immunoregulation could explain the exhaustion of T cell responses that is induced by high viral loads and may serve to down-regulate immune responses." @default.
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• W2076121010 date "1999-10-29" @default.
• W2076121010 modified "2023-10-05" @default.
• W2076121010 title "TCR-Mediated Internalization of Peptide-MHC Complexes Acquired by T Cells" @default.
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• W2076121010 doi "https://doi.org/10.1126/science.286.5441.952" @default.
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