FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076121811> ?p ?o ?g. }

• W2076121811 endingPage "19" @default.
• W2076121811 startingPage "12" @default.
• W2076121811 abstract "The oxytocin receptor specifically requires cholesterol to maintain and stabilize its high-affinity agonist binding. Here, we applied a receptor chimeric approach to coarsely localize the cholesterol binding domain of the oxytocin receptor. During these studies, we identified the specific dependence on cholesterol as a common property of the oxytocin–vasopressin receptor family. We asked whether the oxytocin receptor maintains or loses its cholesterol dependence when parts of the receptor are exchanged by the corresponding fragments of the cholecystokinin receptor that does not show a specific cholesterol dependence. One of the chimeric receptors revealed full oxytocin binding activity, was capable of signal transduction, and its cholesterol dependence was nearly indistinguishable from that of the oxytocin receptor itself. The data suggest that at least the C-terminal segments of the oxytocin receptor including transmembrane domains 6 and 7 do not participate in cholesterol binding. Thus, the binding sites for the modulator cholesterol and for the agonist oxytocin are therefore most likely colocalized in the N-terminal segment of the oxytocin receptor." @default.
• W2076121811 created "2016-06-24" @default.
• W2076121811 creator A5035614057 @default.
• W2076121811 creator A5035641120 @default.
• W2076121811 date "2012-02-01" @default.
• W2076121811 modified "2023-10-09" @default.
• W2076121811 title "Specification of the cholesterol interaction with the oxytocin receptor using a chimeric receptor approach" @default.
• W2076121811 cites W1497754562 @default.
• W2076121811 cites W15271215 @default.
• W2076121811 cites W1546471861 @default.
• W2076121811 cites W1571978724 @default.
• W2076121811 cites W1975740938 @default.
• W2076121811 cites W1979166300 @default.
• W2076121811 cites W1985831230 @default.
• W2076121811 cites W1987506105 @default.
• W2076121811 cites W1987672555 @default.
• W2076121811 cites W1988987153 @default.
• W2076121811 cites W1994373236 @default.
• W2076121811 cites W1996338088 @default.
• W2076121811 cites W2006933211 @default.
• W2076121811 cites W2010122297 @default.
• W2076121811 cites W2019807914 @default.
• W2076121811 cites W2020185913 @default.
• W2076121811 cites W2023286308 @default.
• W2076121811 cites W2032967866 @default.
• W2076121811 cites W2033320890 @default.
• W2076121811 cites W2049848440 @default.
• W2076121811 cites W2070885756 @default.
• W2076121811 cites W2071953701 @default.
• W2076121811 cites W2072795452 @default.
• W2076121811 cites W2083831789 @default.
• W2076121811 cites W2086024671 @default.
• W2076121811 cites W2091179696 @default.
• W2076121811 cites W2104477830 @default.
• W2076121811 cites W2119908940 @default.
• W2076121811 cites W2128574930 @default.
• W2076121811 cites W2135720675 @default.
• W2076121811 cites W2164521969 @default.
• W2076121811 cites W2169714739 @default.
• W2076121811 cites W3048187409 @default.
• W2076121811 cites W3100271906 @default.
• W2076121811 cites W4230786392 @default.
• W2076121811 doi "https://doi.org/10.1016/j.ejphar.2011.11.041" @default.
• W2076121811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22178922" @default.
• W2076121811 hasPublicationYear "2012" @default.
• W2076121811 type Work @default.
• W2076121811 sameAs 2076121811 @default.
• W2076121811 citedByCount "16" @default.
• W2076121811 countsByYear W20761218112012 @default.
• W2076121811 countsByYear W20761218112013 @default.
• W2076121811 countsByYear W20761218112014 @default.
• W2076121811 countsByYear W20761218112016 @default.
• W2076121811 countsByYear W20761218112017 @default.
• W2076121811 countsByYear W20761218112018 @default.
• W2076121811 countsByYear W20761218112020 @default.
• W2076121811 countsByYear W20761218112021 @default.
• W2076121811 countsByYear W20761218112023 @default.
• W2076121811 crossrefType "journal-article" @default.
• W2076121811 hasAuthorship W2076121811A5035614057 @default.
• W2076121811 hasAuthorship W2076121811A5035641120 @default.
• W2076121811 hasConcept C104317684 @default.
• W2076121811 hasConcept C116016267 @default.
• W2076121811 hasConcept C126322002 @default.
• W2076121811 hasConcept C134018914 @default.
• W2076121811 hasConcept C170493617 @default.
• W2076121811 hasConcept C181612422 @default.
• W2076121811 hasConcept C185592680 @default.
• W2076121811 hasConcept C2776176026 @default.
• W2076121811 hasConcept C2776885963 @default.
• W2076121811 hasConcept C2778938600 @default.
• W2076121811 hasConcept C55493867 @default.
• W2076121811 hasConcept C63932345 @default.
• W2076121811 hasConcept C71924100 @default.
• W2076121811 hasConcept C75184817 @default.
• W2076121811 hasConcept C86339819 @default.
• W2076121811 hasConcept C86803240 @default.
• W2076121811 hasConcept C90474776 @default.
• W2076121811 hasConcept C91977512 @default.
• W2076121811 hasConceptScore W2076121811C104317684 @default.
• W2076121811 hasConceptScore W2076121811C116016267 @default.
• W2076121811 hasConceptScore W2076121811C126322002 @default.
• W2076121811 hasConceptScore W2076121811C134018914 @default.
• W2076121811 hasConceptScore W2076121811C170493617 @default.
• W2076121811 hasConceptScore W2076121811C181612422 @default.
• W2076121811 hasConceptScore W2076121811C185592680 @default.
• W2076121811 hasConceptScore W2076121811C2776176026 @default.
• W2076121811 hasConceptScore W2076121811C2776885963 @default.
• W2076121811 hasConceptScore W2076121811C2778938600 @default.
• W2076121811 hasConceptScore W2076121811C55493867 @default.
• W2076121811 hasConceptScore W2076121811C63932345 @default.
• W2076121811 hasConceptScore W2076121811C71924100 @default.
• W2076121811 hasConceptScore W2076121811C75184817 @default.
• W2076121811 hasConceptScore W2076121811C86339819 @default.
• W2076121811 hasConceptScore W2076121811C86803240 @default.
• W2076121811 hasConceptScore W2076121811C90474776 @default.
• W2076121811 hasConceptScore W2076121811C91977512 @default.
• W2076121811 hasIssue "1-3" @default.
• W2076121811 hasLocation W20761218111 @default.

• next