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• W2076124694 abstract "A 644-membered library of chalcones was prepared by parallel synthesis using the Claisen−Schmidt base-catalyzed aldol condensation of substituted acetophenones and benzaldehydes. The cytotoxicity of these chalcones was conveniently determined upon the crude products directly in 96-well microtiter test plates by the conventional MTT assay. This method revealed seven chalcones of IC50 less than 1 μM of which 4‘-hydroxy-2,4,6,3‘-tetramethoxychalcone (5a) was the most active [IC50 (K562), 30 nM]; it causes cell cycle arrest at the G2/M point and binds to tubulin at the colchicine binding site." @default.
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• W2076124694 date "2001-06-29" @default.
• W2076124694 modified "2023-10-03" @default.
• W2076124694 title "Linked Parallel Synthesis and MTT Bioassay Screening of Substituted Chalcones" @default.
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• W2076124694 doi "https://doi.org/10.1021/cc000075z" @default.
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