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- W2076129223 abstract "High-risk (HR) acute lymphoblastic leukemia (ALL) remains one of the greatest challenges in pediatric oncology. Relapsed ALL is a leading cause of death in young people, and further improvements in outcome will required the development of therapeutic approaches directed against rational therapeutic targets, as escalation of the intensity of existing therapies is limited by toxicity. This review summarizes advances in the biology and treatment of HR and relapsed ALL presented at a symposium at the 2010 American Society for Pediatric Hematology and Oncology Annual Meeting. Analysis of large patient cohorts has identified several factors associated with HR of relapse including older age, T-lineage disease, and persisting minimal residual disease (MRD) early in therapy. As the results of salvage therapy remain poor, new treatment approaches are needed. BCR-ABL1-positive (Ph+) ALL has historically had a very poor outcome, but recent studies have demonstrated the impressive improvements in treatment outcome with the use of tyrosine kinase inhibitors (TKIs). High-resolution genomic profiling of genetic alterations and gene expression has revolutionized our understanding of the genetic basis of ALL, and has identified several alterations associated with poor outcome, including mutations of the lymphoid transcription factor gene IKZF1 (IKAROS), activating mutations of Janus kinases, and rearrangement of the lymphoid cytokine receptor gene CRLF2. These data indicated that the genetic basis of HR-ALL is multifactorial, and have also provided a new potential therapeutic option directed at JAK inhibition." @default.
- W2076129223 created "2016-06-24" @default.
- W2076129223 creator A5010840699 @default.
- W2076129223 creator A5023214494 @default.
- W2076129223 creator A5024573751 @default.
- W2076129223 creator A5048744038 @default.
- W2076129223 date "2011-02-15" @default.
- W2076129223 modified "2023-10-16" @default.
- W2076129223 title "Improving outcomes for high-risk ALL: Translating new discoveries into clinical care" @default.
- W2076129223 cites W1532255091 @default.
- W2076129223 cites W155212143 @default.
- W2076129223 cites W1840489083 @default.
- W2076129223 cites W1944430150 @default.
- W2076129223 cites W1966572017 @default.
- W2076129223 cites W1968013647 @default.
- W2076129223 cites W1968390239 @default.
- W2076129223 cites W1970091268 @default.
- W2076129223 cites W1970473877 @default.
- W2076129223 cites W1970474384 @default.
- W2076129223 cites W1972804480 @default.
- W2076129223 cites W1976762027 @default.
- W2076129223 cites W1977190709 @default.
- W2076129223 cites W1978709366 @default.
- W2076129223 cites W1983393070 @default.
- W2076129223 cites W1984065010 @default.
- W2076129223 cites W1987294127 @default.
- W2076129223 cites W1987446594 @default.
- W2076129223 cites W1993275235 @default.
- W2076129223 cites W1994700885 @default.
- W2076129223 cites W1996838280 @default.
- W2076129223 cites W1998593414 @default.
- W2076129223 cites W2000116184 @default.
- W2076129223 cites W2001993817 @default.
- W2076129223 cites W2003973314 @default.
- W2076129223 cites W2005564292 @default.
- W2076129223 cites W2007658436 @default.
- W2076129223 cites W2012114257 @default.
- W2076129223 cites W2016086822 @default.
- W2076129223 cites W2020092689 @default.
- W2076129223 cites W2027227806 @default.
- W2076129223 cites W2028104399 @default.
- W2076129223 cites W2028959752 @default.
- W2076129223 cites W2032564152 @default.
- W2076129223 cites W2036999612 @default.
- W2076129223 cites W2037522752 @default.
- W2076129223 cites W2037896121 @default.
- W2076129223 cites W2040329520 @default.
- W2076129223 cites W2040396943 @default.
- W2076129223 cites W2041410931 @default.
- W2076129223 cites W2044499590 @default.
- W2076129223 cites W2053693702 @default.
- W2076129223 cites W2053754416 @default.
- W2076129223 cites W2054753195 @default.
- W2076129223 cites W2059999488 @default.
- W2076129223 cites W2060383229 @default.
- W2076129223 cites W2060833726 @default.
- W2076129223 cites W2063207305 @default.
- W2076129223 cites W2069709802 @default.
- W2076129223 cites W2071700698 @default.
- W2076129223 cites W2073449138 @default.
- W2076129223 cites W2075139424 @default.
- W2076129223 cites W2076372887 @default.
- W2076129223 cites W2079645940 @default.
- W2076129223 cites W2090340916 @default.
- W2076129223 cites W2092925278 @default.
- W2076129223 cites W2096336184 @default.
- W2076129223 cites W2101587340 @default.
- W2076129223 cites W2105435030 @default.
- W2076129223 cites W2109279774 @default.
- W2076129223 cites W2116335144 @default.
- W2076129223 cites W2119967034 @default.
- W2076129223 cites W2123633897 @default.
- W2076129223 cites W2136334823 @default.
- W2076129223 cites W2139969490 @default.
- W2076129223 cites W2140148690 @default.
- W2076129223 cites W2142940006 @default.
- W2076129223 cites W2145968395 @default.
- W2076129223 cites W2146319645 @default.
- W2076129223 cites W2148428061 @default.
- W2076129223 cites W2148854558 @default.
- W2076129223 cites W2154267224 @default.
- W2076129223 cites W2157460080 @default.
- W2076129223 cites W2157838058 @default.
- W2076129223 cites W2158156131 @default.
- W2076129223 cites W2167135900 @default.
- W2076129223 cites W2169758210 @default.
- W2076129223 cites W2169808956 @default.
- W2076129223 cites W2169916845 @default.
- W2076129223 cites W2170116522 @default.
- W2076129223 cites W2170692626 @default.
- W2076129223 cites W2276967310 @default.
- W2076129223 cites W2312283368 @default.
- W2076129223 cites W2312804644 @default.
- W2076129223 cites W2313577290 @default.
- W2076129223 cites W2334797136 @default.
- W2076129223 cites W2528656428 @default.
- W2076129223 cites W2546302760 @default.
- W2076129223 cites W2585466194 @default.