Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076134308> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2076134308 endingPage "2381" @default.
- W2076134308 startingPage "2380" @default.
- W2076134308 abstract "A novel, conformationally preorganized nonnucleosidic universal solid support for oligonucleotide synthesis was developed. The solid support featured two chemically equivalent hydroxy groups locked in syn-periplanar orientation and orthogonally protected with 4,4'-dimethoxytrityl and acetyl groups. The solid support was extensively tested in the preparation of oligonucleotides and their phosphorothioate analogues containing 2'-deoxy, 2'-O-methyl, and 2'-O-methoxyethylnucleoside residues at the 3'-terminus. Upon completion of oligonucleotide chain assembly, the support-bound oligonucleotide material was treated with concentrated ammonium hydroxide, which removed the O-acetyl protection. The deprotected hydroxy group then effected the transesterification of a phosphate linkage between the solid support and the 3'-terminal nucleoside residue to result in a facile release of the oligonucleotide to solution. The kinetics of the release process was studied in a continuous flow of concentrated aqueous ammonium hydroxide at a temperature of 300.15 K. Optimal conditions for the release of oligonucleotides depending on the chemistry of the backbone and 3'-terminal nucleoside residue were formulated." @default.
- W2076134308 created "2016-06-24" @default.
- W2076134308 creator A5038911866 @default.
- W2076134308 creator A5085203302 @default.
- W2076134308 date "2003-02-08" @default.
- W2076134308 modified "2023-10-12" @default.
- W2076134308 title "A Conformationally Preorganized Universal Solid Support for Efficient Oligonucleotide Synthesis" @default.
- W2076134308 cites W2015293171 @default.
- W2076134308 cites W2050660988 @default.
- W2076134308 doi "https://doi.org/10.1021/ja0284613" @default.
- W2076134308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12603111" @default.
- W2076134308 hasPublicationYear "2003" @default.
- W2076134308 type Work @default.
- W2076134308 sameAs 2076134308 @default.
- W2076134308 citedByCount "33" @default.
- W2076134308 countsByYear W20761343082012 @default.
- W2076134308 countsByYear W20761343082013 @default.
- W2076134308 countsByYear W20761343082014 @default.
- W2076134308 countsByYear W20761343082017 @default.
- W2076134308 countsByYear W20761343082018 @default.
- W2076134308 countsByYear W20761343082019 @default.
- W2076134308 countsByYear W20761343082020 @default.
- W2076134308 countsByYear W20761343082021 @default.
- W2076134308 countsByYear W20761343082022 @default.
- W2076134308 countsByYear W20761343082023 @default.
- W2076134308 crossrefType "journal-article" @default.
- W2076134308 hasAuthorship W2076134308A5038911866 @default.
- W2076134308 hasAuthorship W2076134308A5085203302 @default.
- W2076134308 hasConcept C104317684 @default.
- W2076134308 hasConcept C129312508 @default.
- W2076134308 hasConcept C178790620 @default.
- W2076134308 hasConcept C184651966 @default.
- W2076134308 hasConcept C185592680 @default.
- W2076134308 hasConcept C21951064 @default.
- W2076134308 hasConcept C24107716 @default.
- W2076134308 hasConcept C2775896084 @default.
- W2076134308 hasConcept C2776043002 @default.
- W2076134308 hasConcept C2776469878 @default.
- W2076134308 hasConcept C2776543447 @default.
- W2076134308 hasConcept C2777879272 @default.
- W2076134308 hasConcept C2779281246 @default.
- W2076134308 hasConcept C2781338088 @default.
- W2076134308 hasConcept C512185932 @default.
- W2076134308 hasConcept C552990157 @default.
- W2076134308 hasConcept C55493867 @default.
- W2076134308 hasConcept C68804670 @default.
- W2076134308 hasConcept C71240020 @default.
- W2076134308 hasConceptScore W2076134308C104317684 @default.
- W2076134308 hasConceptScore W2076134308C129312508 @default.
- W2076134308 hasConceptScore W2076134308C178790620 @default.
- W2076134308 hasConceptScore W2076134308C184651966 @default.
- W2076134308 hasConceptScore W2076134308C185592680 @default.
- W2076134308 hasConceptScore W2076134308C21951064 @default.
- W2076134308 hasConceptScore W2076134308C24107716 @default.
- W2076134308 hasConceptScore W2076134308C2775896084 @default.
- W2076134308 hasConceptScore W2076134308C2776043002 @default.
- W2076134308 hasConceptScore W2076134308C2776469878 @default.
- W2076134308 hasConceptScore W2076134308C2776543447 @default.
- W2076134308 hasConceptScore W2076134308C2777879272 @default.
- W2076134308 hasConceptScore W2076134308C2779281246 @default.
- W2076134308 hasConceptScore W2076134308C2781338088 @default.
- W2076134308 hasConceptScore W2076134308C512185932 @default.
- W2076134308 hasConceptScore W2076134308C552990157 @default.
- W2076134308 hasConceptScore W2076134308C55493867 @default.
- W2076134308 hasConceptScore W2076134308C68804670 @default.
- W2076134308 hasConceptScore W2076134308C71240020 @default.
- W2076134308 hasIssue "9" @default.
- W2076134308 hasLocation W20761343081 @default.
- W2076134308 hasLocation W20761343082 @default.
- W2076134308 hasOpenAccess W2076134308 @default.
- W2076134308 hasPrimaryLocation W20761343081 @default.
- W2076134308 hasRelatedWork W1586905266 @default.
- W2076134308 hasRelatedWork W2010679856 @default.
- W2076134308 hasRelatedWork W2037128746 @default.
- W2076134308 hasRelatedWork W2052981377 @default.
- W2076134308 hasRelatedWork W2076134308 @default.
- W2076134308 hasRelatedWork W2077561809 @default.
- W2076134308 hasRelatedWork W2088680077 @default.
- W2076134308 hasRelatedWork W2095413600 @default.
- W2076134308 hasRelatedWork W2741611916 @default.
- W2076134308 hasRelatedWork W2949261754 @default.
- W2076134308 hasVolume "125" @default.
- W2076134308 isParatext "false" @default.
- W2076134308 isRetracted "false" @default.
- W2076134308 magId "2076134308" @default.
- W2076134308 workType "article" @default.