Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076134478> ?p ?o ?g. }
- W2076134478 endingPage "334" @default.
- W2076134478 startingPage "325" @default.
- W2076134478 abstract "Garlic (Allium sativum) has been suggested to affect several cardiovascular risk factors. Its antiatherosclerotic properties are mainly attributed to allicin that is produced upon crushing of the garlic clove. Most previous studies used various garlic preparations in which allicin levels were not well defined. In the present study, we evaluated the effects of pure allicin on atherogenesis in experimental mouse models.Daily dietary supplement of allicin, 9 mg/kg body weight, reduced the atherosclerotic plaque area by 68.9 and 56.8% in apolipoprotein E-deficient and low-density lipoprotein (LDL) receptor knockout mice, respectively, as compared with control mice. LDL isolated from allicin-treated groups was more resistant to CuSO(4)-induced oxidation ex vivo than LDL isolated from control mice. Incubation of mouse plasma with (3)H-labeled allicin showed binding of allicin to lipoproteins. By using electron spin resonance, we demonstrated reduced Cu(2+) binding to LDL following allicin treatment. LDL treatment with allicin significantly inhibited both native LDL and oxidized LDL degradation by isolated mouse macrophages.By using a pure allicin preparation, we were able to show that allicin may affect atherosclerosis not only by acting as an antioxidant, but also by other mechanisms, such as lipoprotein modification and inhibition of LDL uptake and degradation by macrophages." @default.
- W2076134478 created "2016-06-24" @default.
- W2076134478 creator A5006553308 @default.
- W2076134478 creator A5041666216 @default.
- W2076134478 creator A5056516356 @default.
- W2076134478 creator A5057187994 @default.
- W2076134478 creator A5068143704 @default.
- W2076134478 creator A5070045481 @default.
- W2076134478 creator A5070679444 @default.
- W2076134478 creator A5073154471 @default.
- W2076134478 creator A5075176331 @default.
- W2076134478 creator A5075241762 @default.
- W2076134478 creator A5091163677 @default.
- W2076134478 date "2005-01-01" @default.
- W2076134478 modified "2023-10-14" @default.
- W2076134478 title "The Antiatherogenic Effect of Allicin: Possible Mode of Action" @default.
- W2076134478 cites W1512559452 @default.
- W2076134478 cites W1522459970 @default.
- W2076134478 cites W1650965741 @default.
- W2076134478 cites W1775749144 @default.
- W2076134478 cites W1840158612 @default.
- W2076134478 cites W1888327048 @default.
- W2076134478 cites W1904312815 @default.
- W2076134478 cites W1922580849 @default.
- W2076134478 cites W1943303117 @default.
- W2076134478 cites W1964476694 @default.
- W2076134478 cites W1969275151 @default.
- W2076134478 cites W1975378692 @default.
- W2076134478 cites W1976616659 @default.
- W2076134478 cites W1982789996 @default.
- W2076134478 cites W1987274369 @default.
- W2076134478 cites W1988192085 @default.
- W2076134478 cites W1990340361 @default.
- W2076134478 cites W1995889718 @default.
- W2076134478 cites W2004059961 @default.
- W2076134478 cites W2007074608 @default.
- W2076134478 cites W2009613165 @default.
- W2076134478 cites W2013137776 @default.
- W2076134478 cites W2017373329 @default.
- W2076134478 cites W2031061369 @default.
- W2076134478 cites W2032319297 @default.
- W2076134478 cites W2034345979 @default.
- W2076134478 cites W2036154701 @default.
- W2076134478 cites W2037680251 @default.
- W2076134478 cites W2055769329 @default.
- W2076134478 cites W2058164136 @default.
- W2076134478 cites W2059916134 @default.
- W2076134478 cites W2060360501 @default.
- W2076134478 cites W2062558937 @default.
- W2076134478 cites W2064551081 @default.
- W2076134478 cites W2065341379 @default.
- W2076134478 cites W2066794295 @default.
- W2076134478 cites W2069893094 @default.
- W2076134478 cites W2079358577 @default.
- W2076134478 cites W2084155565 @default.
- W2076134478 cites W2089385972 @default.
- W2076134478 cites W2096099147 @default.
- W2076134478 cites W2096330168 @default.
- W2076134478 cites W2112419020 @default.
- W2076134478 cites W2119864416 @default.
- W2076134478 cites W2120290727 @default.
- W2076134478 cites W2134010411 @default.
- W2076134478 cites W2139012018 @default.
- W2076134478 cites W2150351630 @default.
- W2076134478 cites W2156553719 @default.
- W2076134478 cites W2164245596 @default.
- W2076134478 cites W2167607881 @default.
- W2076134478 cites W2313837936 @default.
- W2076134478 cites W2323989609 @default.
- W2076134478 cites W2414636159 @default.
- W2076134478 cites W2422348182 @default.
- W2076134478 cites W2438408612 @default.
- W2076134478 cites W2900726862 @default.
- W2076134478 doi "https://doi.org/10.1159/000091330" @default.
- W2076134478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16582584" @default.
- W2076134478 hasPublicationYear "2005" @default.
- W2076134478 type Work @default.
- W2076134478 sameAs 2076134478 @default.
- W2076134478 citedByCount "95" @default.
- W2076134478 countsByYear W20761344782012 @default.
- W2076134478 countsByYear W20761344782013 @default.
- W2076134478 countsByYear W20761344782014 @default.
- W2076134478 countsByYear W20761344782015 @default.
- W2076134478 countsByYear W20761344782016 @default.
- W2076134478 countsByYear W20761344782017 @default.
- W2076134478 countsByYear W20761344782018 @default.
- W2076134478 countsByYear W20761344782019 @default.
- W2076134478 countsByYear W20761344782020 @default.
- W2076134478 countsByYear W20761344782021 @default.
- W2076134478 countsByYear W20761344782022 @default.
- W2076134478 countsByYear W20761344782023 @default.
- W2076134478 crossrefType "journal-article" @default.
- W2076134478 hasAuthorship W2076134478A5006553308 @default.
- W2076134478 hasAuthorship W2076134478A5041666216 @default.
- W2076134478 hasAuthorship W2076134478A5056516356 @default.
- W2076134478 hasAuthorship W2076134478A5057187994 @default.
- W2076134478 hasAuthorship W2076134478A5068143704 @default.
- W2076134478 hasAuthorship W2076134478A5070045481 @default.