FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076139825> ?p ?o ?g. }

• W2076139825 abstract "BackgroundWhile the association between affective disorders and sleep and circadian disturbance is well established, little is known about the neurobiology underpinning these relationships. In this study, we sought to determine the relationship between a marker of circadian rhythm and neuronal integrity (N-Acetyl Aspartate, NAA), oxidative stress (glutathione, GSH) and neuronal-glial dysfunction (Glutamate + Glutamine, Glx).MethodsFifty-three young adults (age range 15–33 years, mean = 21.8, sd = 4.3) with emerging affective disorders were recruited from a specialized tertiary referral service. Participants underwent clinical assessment and actigraphy monitoring, from which sleep midpoint was calculated as a marker of circadian rhythm. Proton magnetic resonance spectroscopy was performed in the anterior cingulate cortex (ACC). The metabolites NAA, GSH and Glx were obtained, and expressed as a ratio to Creatine.ResultsNeither NAA or GSH were associated with sleep midpoint. However, higher levels of ACC Glx were associated with later sleep midpoints (rho = 0.35, p = 0.013). This relationship appeared to be independent of age and depression severity.ConclusionsThis study is the first to demonstrate that delayed circadian phase is related to altered glutamatergic processes. It is aligned with animal research linking circadian rhythms with glutamatergic neurotransmission as well as clinical studies showing changes in glutamate with sleep interventions. Further studies may seek to examine the role of glutamate modulators for circadian misalignment." @default.
• W2076139825 created "2016-06-24" @default.
• W2076139825 creator A5007003603 @default.
• W2076139825 creator A5008223546 @default.
• W2076139825 creator A5039492331 @default.
• W2076139825 creator A5041201452 @default.
• W2076139825 creator A5069078473 @default.
• W2076139825 creator A5073711971 @default.
• W2076139825 creator A5077825658 @default.
• W2076139825 creator A5078360660 @default.
• W2076139825 date "2014-12-01" @default.
• W2076139825 modified "2023-09-26" @default.
• W2076139825 title "Delayed circadian phase is linked to glutamatergic functions in young people with affective disorders: a proton magnetic resonance spectroscopy study" @default.
• W2076139825 cites W1493831458 @default.
• W2076139825 cites W1963751716 @default.
• W2076139825 cites W1966006827 @default.
• W2076139825 cites W1966723957 @default.
• W2076139825 cites W1973350840 @default.
• W2076139825 cites W1973978813 @default.
• W2076139825 cites W1988527761 @default.
• W2076139825 cites W1992633305 @default.
• W2076139825 cites W1993195217 @default.
• W2076139825 cites W1999903654 @default.
• W2076139825 cites W2005523478 @default.
• W2076139825 cites W2008772155 @default.
• W2076139825 cites W2016409713 @default.
• W2076139825 cites W2019190564 @default.
• W2076139825 cites W2019685634 @default.
• W2076139825 cites W2020161011 @default.
• W2076139825 cites W2033264902 @default.
• W2076139825 cites W2034072665 @default.
• W2076139825 cites W2038979894 @default.
• W2076139825 cites W2040344668 @default.
• W2076139825 cites W2041096350 @default.
• W2076139825 cites W2043323573 @default.
• W2076139825 cites W2052890134 @default.
• W2076139825 cites W2055544479 @default.
• W2076139825 cites W2055656488 @default.
• W2076139825 cites W2055975886 @default.
• W2076139825 cites W2056850743 @default.
• W2076139825 cites W2057534528 @default.
• W2076139825 cites W2062414779 @default.
• W2076139825 cites W2075562407 @default.
• W2076139825 cites W2076299279 @default.
• W2076139825 cites W2082178595 @default.
• W2076139825 cites W2092226172 @default.
• W2076139825 cites W2103565828 @default.
• W2076139825 cites W2104247936 @default.
• W2076139825 cites W2107278158 @default.
• W2076139825 cites W2114032601 @default.
• W2076139825 cites W2114613490 @default.
• W2076139825 cites W2134977136 @default.
• W2076139825 cites W2147865589 @default.
• W2076139825 cites W2148665968 @default.
• W2076139825 cites W2163145097 @default.
• W2076139825 cites W2167659819 @default.
• W2076139825 doi "https://doi.org/10.1186/s12888-014-0345-1" @default.
• W2076139825 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4276104" @default.
• W2076139825 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25496061" @default.
• W2076139825 hasPublicationYear "2014" @default.
• W2076139825 type Work @default.
• W2076139825 sameAs 2076139825 @default.
• W2076139825 citedByCount "11" @default.
• W2076139825 countsByYear W20761398252016 @default.
• W2076139825 countsByYear W20761398252017 @default.
• W2076139825 countsByYear W20761398252018 @default.
• W2076139825 countsByYear W20761398252019 @default.
• W2076139825 countsByYear W20761398252020 @default.
• W2076139825 countsByYear W20761398252021 @default.
• W2076139825 crossrefType "journal-article" @default.
• W2076139825 hasAuthorship W2076139825A5007003603 @default.
• W2076139825 hasAuthorship W2076139825A5008223546 @default.
• W2076139825 hasAuthorship W2076139825A5039492331 @default.
• W2076139825 hasAuthorship W2076139825A5041201452 @default.
• W2076139825 hasAuthorship W2076139825A5069078473 @default.
• W2076139825 hasAuthorship W2076139825A5073711971 @default.
• W2076139825 hasAuthorship W2076139825A5077825658 @default.
• W2076139825 hasAuthorship W2076139825A5078360660 @default.
• W2076139825 hasBestOaLocation W20761398251 @default.
• W2076139825 hasConcept C121446783 @default.
• W2076139825 hasConcept C126322002 @default.
• W2076139825 hasConcept C134018914 @default.
• W2076139825 hasConcept C15744967 @default.
• W2076139825 hasConcept C169760540 @default.
• W2076139825 hasConcept C169900460 @default.
• W2076139825 hasConcept C170493617 @default.
• W2076139825 hasConcept C2778402161 @default.
• W2076139825 hasConcept C2778996325 @default.
• W2076139825 hasConcept C2780648746 @default.
• W2076139825 hasConcept C61174792 @default.
• W2076139825 hasConcept C71924100 @default.
• W2076139825 hasConceptScore W2076139825C121446783 @default.
• W2076139825 hasConceptScore W2076139825C126322002 @default.
• W2076139825 hasConceptScore W2076139825C134018914 @default.
• W2076139825 hasConceptScore W2076139825C15744967 @default.
• W2076139825 hasConceptScore W2076139825C169760540 @default.
• W2076139825 hasConceptScore W2076139825C169900460 @default.
• W2076139825 hasConceptScore W2076139825C170493617 @default.
• W2076139825 hasConceptScore W2076139825C2778402161 @default.
• W2076139825 hasConceptScore W2076139825C2778996325 @default.

• next