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- W2076141366 abstract "Bovine pancreatic ribonuclease B (RNase B) differs from RNase A by the presence of an oligosaccharide moiety covalently attached to Asn 34. Oxidative folding studies of RNase B were carried out at different temperatures using DTT(ox) as the oxidizing agent, and the results were compared with those for RNase A. The oxidative folding rates of RNase B are between 1.7 and 1.3 times faster than those of RNase A at the temperatures that were investigated. The folding pathways of RNase B were determined to be similar to those of RNase A in that two structured intermediates, each lacking one native disulfide bond, were found to populate the regeneration pathways at 25 degrees C and pH 8.3. The thermodynamic stabilities of these two glycosylated intermediates, and their rates of formation from their unstructured precursors in the rate-determining step, were found to be higher than those of their unglycosylated counterparts from RNase A. Thus, the underlying cause for the faster rate of oxidative regeneration of native RNase B appears to be both thermodynamic and kinetic due to the higher stability, and faster rate of formation, of the intermediates of RNase B compared to those of RNase A." @default.
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- W2076141366 date "2005-06-18" @default.
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- W2076141366 title "The Oxidative Folding Rate of Bovine Pancreatic Ribonuclease Is Enhanced by a Covalently Attached Oligosaccharide" @default.
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- W2076141366 doi "https://doi.org/10.1021/bi0506932" @default.
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