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• W2076143217 abstract "Sepsis is a potentially fatal whole-body inflammatory state caused by severe infection, in which a maladaptive, system-wide inflammatory response follows initial attempts to eliminate pathogens, leading to a dangerous and often fatal increase in the permeability of the blood–brain barrier. These changes in the blood–brain barrier might lead to a major symptom of sepsis, sepsis-associated encephalopathy, which manifests as confusion with a rapid decline in cognitive functions, especially memory, or coma. Once presumed to be entirely reversible, research suggests that sepsis-associated encephalopathy could lead to permanent neurocognitive dysfunction and functional impairments, even after the patient has recovered. Sepsis might act as a major inflammatory hit and potentially increase the brain's susceptibility to neurodegenerative disease, further deterioration of cognitive ability, and risk of developing dementia in later life. Key opportunities for neuroprotective interventions and after-care for people who have survived sepsis might be lost because the long-term neurocognitive and functional consequences of sepsis are not fully characterised. Sepsis is a potentially fatal whole-body inflammatory state caused by severe infection, in which a maladaptive, system-wide inflammatory response follows initial attempts to eliminate pathogens, leading to a dangerous and often fatal increase in the permeability of the blood–brain barrier. These changes in the blood–brain barrier might lead to a major symptom of sepsis, sepsis-associated encephalopathy, which manifests as confusion with a rapid decline in cognitive functions, especially memory, or coma. Once presumed to be entirely reversible, research suggests that sepsis-associated encephalopathy could lead to permanent neurocognitive dysfunction and functional impairments, even after the patient has recovered. Sepsis might act as a major inflammatory hit and potentially increase the brain's susceptibility to neurodegenerative disease, further deterioration of cognitive ability, and risk of developing dementia in later life. Key opportunities for neuroprotective interventions and after-care for people who have survived sepsis might be lost because the long-term neurocognitive and functional consequences of sepsis are not fully characterised. Neuropathological processes in sepsisSepsis is a life-threatening condition that is often revealed or complicated by an encephalopathy but is not related to a primary brain infection. Sepsis-associated encephalopathy is defined by changes in consciousness, ranging from confusion (ie, delirium) to coma, and is characterised by various electrophysiological changes that have been associated with poor prognosis.1 Diagnosis of sepsis-associated encephalopathy is crucial for avoiding potentially devastating effects and is based on neurological examination that guides further investigations. Full-Text PDF Sepsis-associated encephalopathy versus sepsis-induced encephalopathyWe read with interest the Review by Widmann and Heneka on the long-term consequences of sepsis.1 Sepsis and its associated complications are thought to be the foremost causes of morbidity and mortality in patients in intensive-care units (ICU) worldwide. Sepsis, a potentially fatal sequel to infection, results from a cascade of pro-inflammatory compounds released in response to infection. Consequently, multiple-organ systems might be affected, leading to their failure. Full-Text PDF Sepsis-associated encephalopathy versus sepsis-induced encephalopathy–Authors' replyCognitive and cerebral damage after sepsis could have many causes, and whether sepsis-associated encephalopathy is the only cause is unclear. Furthermore, whether encephalopathy during sepsis is a result of sepsis itself or due to myriad other factors during acute illness is also unclear. Full-Text PDF" @default.
• W2076143217 created "2016-06-24" @default.
• W2076143217 creator A5050660601 @default.
• W2076143217 creator A5078440867 @default.
• W2076143217 date "2014-06-01" @default.
• W2076143217 modified "2023-10-16" @default.
• W2076143217 title "Long-term cerebral consequences of sepsis" @default.
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• W2076143217 doi "https://doi.org/10.1016/s1474-4422(14)70017-1" @default.
• W2076143217 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24849863" @default.
• W2076143217 hasPublicationYear "2014" @default.
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