FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076143575> ?p ?o ?g. }

• W2076143575 endingPage "202" @default.
• W2076143575 startingPage "198" @default.
• W2076143575 abstract "Blockade of spinal glycinergic inhibition with intrathecal (i.t.) strychnine induces a reversible allodynia-like state in both conscious and lightly-anaesthetized rats. Since the locus coeruleus (LC) is activated by noxious stimuli, we determined the effect of non-noxious hair deflection (HD) on noradrenergic neuronal activity in the LC of rats treated with i.t. strychnine. Differential normal pulse voltammetry was used to measure the catechol oxidation current (CA.OC), an index of LC activity. Rats were maintained in a light plane of anaesthesia with i.v. urethane and i.t. strychnine (40 micrograms) was injected near the L1-L2 segment. HD, applied to the caudal dermatomes affected by i.t. strychnine, evoked a significant increase (max. 141 +/- 7%, n = 5, P < 0.05) in CA.OC and mean arterial pressure as compared to baseline (no strychnine). In contrast, HD had no significant effect on CA.OC or mean arterial pressure in the saline-treated rats (n = 5). Pre-treatment with i.t. MK801 (30 micrograms) significantly blocked the increase in CA.OC and mean arterial pressure evoked by HD in strychnine-treated rats. The results of this study indicated that HD, in the presence of i.t. strychnine but not saline, can evoke noradrenergic activity in the LC of lightly anaesthetized rats. This effect on the LC is: (1) comparable to that observed with noxious stimulation without i.t. strychnine; (2) segmentally localized, corresponding to the spinal site of strychnine injection; and (3) mediated by spinal NMDA receptors, consistent with the role of excitatory amino acids in sensory transmission. These data provide the first neurochemical evidence that HD, in the presence of i.t. strychnine, is a nociceptive event, supporting the use of this preparation as an experimental model of allodynia." @default.
• W2076143575 created "2016-06-24" @default.
• W2076143575 creator A5004593402 @default.
• W2076143575 creator A5011854837 @default.
• W2076143575 creator A5016606343 @default.
• W2076143575 creator A5066025545 @default.
• W2076143575 date "1996-04-01" @default.
• W2076143575 modified "2023-09-25" @default.
• W2076143575 title "Innocuous hair deflection evokes a nociceptive-like activation of catechol oxidation in the rat locus coeruleus following intrathecal strychnine: a biochemical index of allodynia using in vivo voltammetry" @default.
• W2076143575 cites W1965591048 @default.
• W2076143575 cites W1981992102 @default.
• W2076143575 cites W1982224198 @default.
• W2076143575 cites W1983666386 @default.
• W2076143575 cites W2008543586 @default.
• W2076143575 cites W2008547040 @default.
• W2076143575 cites W2009647205 @default.
• W2076143575 cites W2033597508 @default.
• W2076143575 cites W2040725197 @default.
• W2076143575 cites W2040761443 @default.
• W2076143575 cites W2041762757 @default.
• W2076143575 cites W2050912650 @default.
• W2076143575 cites W2056682148 @default.
• W2076143575 cites W2058206922 @default.
• W2076143575 cites W2063223361 @default.
• W2076143575 cites W2066497793 @default.
• W2076143575 cites W2074972352 @default.
• W2076143575 cites W2076653836 @default.
• W2076143575 cites W2077802049 @default.
• W2076143575 cites W2092085208 @default.
• W2076143575 cites W2092919118 @default.
• W2076143575 cites W2094556643 @default.
• W2076143575 cites W2155457449 @default.
• W2076143575 cites W4244054492 @default.
• W2076143575 doi "https://doi.org/10.1016/0006-8993(96)00072-8" @default.
• W2076143575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8773787" @default.
• W2076143575 hasPublicationYear "1996" @default.
• W2076143575 type Work @default.
• W2076143575 sameAs 2076143575 @default.
• W2076143575 citedByCount "17" @default.
• W2076143575 countsByYear W20761435752013 @default.
• W2076143575 countsByYear W20761435752015 @default.
• W2076143575 countsByYear W20761435752019 @default.
• W2076143575 crossrefType "journal-article" @default.
• W2076143575 hasAuthorship W2076143575A5004593402 @default.
• W2076143575 hasAuthorship W2076143575A5011854837 @default.
• W2076143575 hasAuthorship W2076143575A5016606343 @default.
• W2076143575 hasAuthorship W2076143575A5066025545 @default.
• W2076143575 hasConcept C104211972 @default.
• W2076143575 hasConcept C126322002 @default.
• W2076143575 hasConcept C134018914 @default.
• W2076143575 hasConcept C15490471 @default.
• W2076143575 hasConcept C170493617 @default.
• W2076143575 hasConcept C185592680 @default.
• W2076143575 hasConcept C24998067 @default.
• W2076143575 hasConcept C2777725853 @default.
• W2076143575 hasConcept C2778468602 @default.
• W2076143575 hasConcept C42219234 @default.
• W2076143575 hasConcept C529278444 @default.
• W2076143575 hasConcept C55493867 @default.
• W2076143575 hasConcept C71924100 @default.
• W2076143575 hasConcept C98274493 @default.
• W2076143575 hasConceptScore W2076143575C104211972 @default.
• W2076143575 hasConceptScore W2076143575C126322002 @default.
• W2076143575 hasConceptScore W2076143575C134018914 @default.
• W2076143575 hasConceptScore W2076143575C15490471 @default.
• W2076143575 hasConceptScore W2076143575C170493617 @default.
• W2076143575 hasConceptScore W2076143575C185592680 @default.
• W2076143575 hasConceptScore W2076143575C24998067 @default.
• W2076143575 hasConceptScore W2076143575C2777725853 @default.
• W2076143575 hasConceptScore W2076143575C2778468602 @default.
• W2076143575 hasConceptScore W2076143575C42219234 @default.
• W2076143575 hasConceptScore W2076143575C529278444 @default.
• W2076143575 hasConceptScore W2076143575C55493867 @default.
• W2076143575 hasConceptScore W2076143575C71924100 @default.
• W2076143575 hasConceptScore W2076143575C98274493 @default.
• W2076143575 hasIssue "1-2" @default.
• W2076143575 hasLocation W20761435751 @default.
• W2076143575 hasLocation W20761435752 @default.
• W2076143575 hasOpenAccess W2076143575 @default.
• W2076143575 hasPrimaryLocation W20761435751 @default.
• W2076143575 hasRelatedWork W1592770056 @default.
• W2076143575 hasRelatedWork W1889309137 @default.
• W2076143575 hasRelatedWork W2019412418 @default.
• W2076143575 hasRelatedWork W2020144632 @default.
• W2076143575 hasRelatedWork W2028493865 @default.
• W2076143575 hasRelatedWork W2034768996 @default.
• W2076143575 hasRelatedWork W2054992011 @default.
• W2076143575 hasRelatedWork W2064416809 @default.
• W2076143575 hasRelatedWork W2075883892 @default.
• W2076143575 hasRelatedWork W2168131586 @default.
• W2076143575 hasVolume "718" @default.
• W2076143575 isParatext "false" @default.
• W2076143575 isRetracted "false" @default.
• W2076143575 magId "2076143575" @default.
• W2076143575 workType "article" @default.