FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076148870> ?p ?o ?g. }

• W2076148870 endingPage "297" @default.
• W2076148870 startingPage "287" @default.
• W2076148870 abstract "Squamous cell carcinoma of the oral cavity (SCC) accounts for 3% of cancers in the western world and 40% of cancers in India. The overall 5-year survival rate is only 50%. Most of the lesions appear intra-orally on the tongue. Results from a previous study demonstrated a significant increase in T and B-lymphocytes under the transformed epithelium when examining human lesions of hyperkeratosis, dysplasia and carcinoma of the tongue. In order to investigate the interaction between the host immunity and SCC, carcinogen induced SCC of the tongue was studied in mice. The water-soluble carcinogen, 4 nitroquinoline N-oxide (4NQO), was applied to BALB/c mice tongues and produced tongue SCC after a long incubation period of several months. Immunologic properties were examined systemically in the spleens and locally, at the tumor site. Examination of spleen lymphocytes from 4NQO induced mice revealed enlargement of the spleens and a significant decrease in the CD3, CD4, CD8 and CD19 cells. In the tongues, expression of TGF-β, TNF-α, GM-CSF, and IL-1β mRNA were detected. TNF-α protein was detected in the affected tongues using immunoassays. mRNA expression of TNF-α was detected in the cancerous epithelium when extracted from the connective tissue. CD11b and CD3 cells were detected in the connective tissue under the developing carcinoma. CD11b positive cells were more prominent. The infiltrate was very scattered and not prominent as the infiltrate in the human tongue tissues. These results indicate that the growing tumor affected the immune response around the tumor and systemically. Most of the cytokines, which appeared in the affected tongues, originated from the tumor surroundings, but TNF-α was found also in the tumor. The interaction between the tumor and immune response components is important for diagnosis and treatment purposes." @default.
• W2076148870 created "2016-06-24" @default.
• W2076148870 creator A5011378386 @default.
• W2076148870 creator A5060604765 @default.
• W2076148870 creator A5084746007 @default.
• W2076148870 date "2004-03-01" @default.
• W2076148870 modified "2023-10-07" @default.
• W2076148870 title "Interaction between the immune system and tongue squamous cell carcinoma induced by 4-nitroquinoline N-oxide in mice" @default.
• W2076148870 cites W1965147813 @default.
• W2076148870 cites W1997226244 @default.
• W2076148870 cites W2006091525 @default.
• W2076148870 cites W2010267706 @default.
• W2076148870 cites W2011576759 @default.
• W2076148870 cites W2017357027 @default.
• W2076148870 cites W2023409915 @default.
• W2076148870 cites W2032217951 @default.
• W2076148870 cites W2034936705 @default.
• W2076148870 cites W2052016996 @default.
• W2076148870 cites W2056419915 @default.
• W2076148870 cites W2066728868 @default.
• W2076148870 cites W2070903674 @default.
• W2076148870 cites W2079900771 @default.
• W2076148870 cites W2084920222 @default.
• W2076148870 cites W2107974042 @default.
• W2076148870 cites W2109847775 @default.
• W2076148870 cites W2113404887 @default.
• W2076148870 cites W2119898926 @default.
• W2076148870 cites W2138699024 @default.
• W2076148870 cites W2163603137 @default.
• W2076148870 cites W2330567364 @default.
• W2076148870 cites W4210286209 @default.
• W2076148870 doi "https://doi.org/10.1016/j.oraloncology.2003.08.008" @default.
• W2076148870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14747060" @default.
• W2076148870 hasPublicationYear "2004" @default.
• W2076148870 type Work @default.
• W2076148870 sameAs 2076148870 @default.
• W2076148870 citedByCount "24" @default.
• W2076148870 countsByYear W20761488702012 @default.
• W2076148870 countsByYear W20761488702013 @default.
• W2076148870 countsByYear W20761488702014 @default.
• W2076148870 countsByYear W20761488702015 @default.
• W2076148870 countsByYear W20761488702017 @default.
• W2076148870 countsByYear W20761488702019 @default.
• W2076148870 countsByYear W20761488702021 @default.
• W2076148870 countsByYear W20761488702022 @default.
• W2076148870 crossrefType "journal-article" @default.
• W2076148870 hasAuthorship W2076148870A5011378386 @default.
• W2076148870 hasAuthorship W2076148870A5060604765 @default.
• W2076148870 hasAuthorship W2076148870A5084746007 @default.
• W2076148870 hasConcept C114246631 @default.
• W2076148870 hasConcept C114684123 @default.
• W2076148870 hasConcept C121608353 @default.
• W2076148870 hasConcept C126322002 @default.
• W2076148870 hasConcept C142724271 @default.
• W2076148870 hasConcept C167672396 @default.
• W2076148870 hasConcept C203014093 @default.
• W2076148870 hasConcept C2779744641 @default.
• W2076148870 hasConcept C2779911484 @default.
• W2076148870 hasConcept C2780931953 @default.
• W2076148870 hasConcept C518705261 @default.
• W2076148870 hasConcept C54355233 @default.
• W2076148870 hasConcept C555283112 @default.
• W2076148870 hasConcept C71924100 @default.
• W2076148870 hasConcept C86803240 @default.
• W2076148870 hasConcept C8891405 @default.
• W2076148870 hasConceptScore W2076148870C114246631 @default.
• W2076148870 hasConceptScore W2076148870C114684123 @default.
• W2076148870 hasConceptScore W2076148870C121608353 @default.
• W2076148870 hasConceptScore W2076148870C126322002 @default.
• W2076148870 hasConceptScore W2076148870C142724271 @default.
• W2076148870 hasConceptScore W2076148870C167672396 @default.
• W2076148870 hasConceptScore W2076148870C203014093 @default.
• W2076148870 hasConceptScore W2076148870C2779744641 @default.
• W2076148870 hasConceptScore W2076148870C2779911484 @default.
• W2076148870 hasConceptScore W2076148870C2780931953 @default.
• W2076148870 hasConceptScore W2076148870C518705261 @default.
• W2076148870 hasConceptScore W2076148870C54355233 @default.
• W2076148870 hasConceptScore W2076148870C555283112 @default.
• W2076148870 hasConceptScore W2076148870C71924100 @default.
• W2076148870 hasConceptScore W2076148870C86803240 @default.
• W2076148870 hasConceptScore W2076148870C8891405 @default.
• W2076148870 hasIssue "3" @default.
• W2076148870 hasLocation W20761488701 @default.
• W2076148870 hasLocation W20761488702 @default.
• W2076148870 hasOpenAccess W2076148870 @default.
• W2076148870 hasPrimaryLocation W20761488701 @default.
• W2076148870 hasRelatedWork W2000722792 @default.
• W2076148870 hasRelatedWork W2043970937 @default.
• W2076148870 hasRelatedWork W2052284404 @default.
• W2076148870 hasRelatedWork W2063439005 @default.
• W2076148870 hasRelatedWork W2078668145 @default.
• W2076148870 hasRelatedWork W2151876858 @default.
• W2076148870 hasRelatedWork W2160523948 @default.
• W2076148870 hasRelatedWork W2161433098 @default.
• W2076148870 hasRelatedWork W2200939991 @default.
• W2076148870 hasRelatedWork W2219671671 @default.
• W2076148870 hasVolume "40" @default.
• W2076148870 isParatext "false" @default.

• next