Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076149318> ?p ?o ?g. }
- W2076149318 endingPage "918" @default.
- W2076149318 startingPage "909" @default.
- W2076149318 abstract "1. Although cholecystokinin octapeptide sulphate (CCK-8) activates the opioid system of isolated guinea-pig ileum (GPI) whether it activates the mu- or kappa-system, or both, remains unclear. Neither is it known whether CCK-8 influences the withdrawal responses in GPI preparations briefly exposed to opioid agonists. This study was designed to clarify whether CCK-8 activates mu- or kappa-opioid systems or both; and to investigate its effect on the withdrawal contractures in GPI exposed to mu- or kappa-agonists and on the development of tolerance to the withdrawal response. 2. In GPI exposed to CCK-8, the selective kappa-antagonist nor-binaltorphimine elicited contractile responses that were concentration-related to CCK-8 whereas the selective mu-antagonist cyprodime did not. 3. In GPI preparations briefly exposed to the selective mu-agonist, dermorphin, or the selective kappa-agonist, U-50, 488H, and then challenged with naloxone, CCK-8 strongly enhanced the withdrawal contractures. 4. During repeated opioid agonist/CCK-8/opioid antagonist tests tolerance to opioid-induced withdrawal responses did not develop. 5. These results show that CCK-8 preferentially activates the GPI kappa-opioid system and antagonizes the mechanism(s) that control the expression of acute dependence in the GPI." @default.
- W2076149318 created "2016-06-24" @default.
- W2076149318 creator A5009957634 @default.
- W2076149318 creator A5024036513 @default.
- W2076149318 creator A5036803515 @default.
- W2076149318 creator A5041433991 @default.
- W2076149318 creator A5073640583 @default.
- W2076149318 date "1999-06-01" @default.
- W2076149318 modified "2023-09-24" @default.
- W2076149318 title "Interactions between cholecystokinin and opioids in the isolated guinea-pig ileum" @default.
- W2076149318 cites W1908503105 @default.
- W2076149318 cites W1914342883 @default.
- W2076149318 cites W1942352830 @default.
- W2076149318 cites W1944103599 @default.
- W2076149318 cites W1963292275 @default.
- W2076149318 cites W1965469213 @default.
- W2076149318 cites W1976224483 @default.
- W2076149318 cites W1986832734 @default.
- W2076149318 cites W1991546010 @default.
- W2076149318 cites W1991842959 @default.
- W2076149318 cites W1995042919 @default.
- W2076149318 cites W1996084065 @default.
- W2076149318 cites W1998348531 @default.
- W2076149318 cites W2004401380 @default.
- W2076149318 cites W2006532644 @default.
- W2076149318 cites W2006782729 @default.
- W2076149318 cites W2007031216 @default.
- W2076149318 cites W2007793135 @default.
- W2076149318 cites W2013445319 @default.
- W2076149318 cites W2014110722 @default.
- W2076149318 cites W2015857024 @default.
- W2076149318 cites W2016460078 @default.
- W2076149318 cites W2017483076 @default.
- W2076149318 cites W2021687069 @default.
- W2076149318 cites W2026085960 @default.
- W2076149318 cites W2027515750 @default.
- W2076149318 cites W2037033078 @default.
- W2076149318 cites W2039409606 @default.
- W2076149318 cites W2041422140 @default.
- W2076149318 cites W2050234840 @default.
- W2076149318 cites W2055391107 @default.
- W2076149318 cites W2061416663 @default.
- W2076149318 cites W2062129106 @default.
- W2076149318 cites W2064625813 @default.
- W2076149318 cites W2065619895 @default.
- W2076149318 cites W2072042679 @default.
- W2076149318 cites W2072073000 @default.
- W2076149318 cites W2076022212 @default.
- W2076149318 cites W2076462785 @default.
- W2076149318 cites W2076758126 @default.
- W2076149318 cites W2076849577 @default.
- W2076149318 cites W2080273215 @default.
- W2076149318 cites W2093800476 @default.
- W2076149318 cites W2116883604 @default.
- W2076149318 cites W2133842509 @default.
- W2076149318 cites W2159439931 @default.
- W2076149318 cites W2179081865 @default.
- W2076149318 cites W2256108332 @default.
- W2076149318 cites W2269364833 @default.
- W2076149318 cites W2338102590 @default.
- W2076149318 cites W2412771099 @default.
- W2076149318 cites W4247689076 @default.
- W2076149318 doi "https://doi.org/10.1038/sj.bjp.0702621" @default.
- W2076149318 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1566095" @default.
- W2076149318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10433498" @default.
- W2076149318 hasPublicationYear "1999" @default.
- W2076149318 type Work @default.
- W2076149318 sameAs 2076149318 @default.
- W2076149318 citedByCount "8" @default.
- W2076149318 countsByYear W20761493182012 @default.
- W2076149318 countsByYear W20761493182015 @default.
- W2076149318 crossrefType "journal-article" @default.
- W2076149318 hasAuthorship W2076149318A5009957634 @default.
- W2076149318 hasAuthorship W2076149318A5024036513 @default.
- W2076149318 hasAuthorship W2076149318A5036803515 @default.
- W2076149318 hasAuthorship W2076149318A5041433991 @default.
- W2076149318 hasAuthorship W2076149318A5073640583 @default.
- W2076149318 hasBestOaLocation W20761493181 @default.
- W2076149318 hasConcept C126322002 @default.
- W2076149318 hasConcept C134018914 @default.
- W2076149318 hasConcept C170493617 @default.
- W2076149318 hasConcept C184389661 @default.
- W2076149318 hasConcept C185592680 @default.
- W2076149318 hasConcept C2775962371 @default.
- W2076149318 hasConcept C2776885963 @default.
- W2076149318 hasConcept C2777593968 @default.
- W2076149318 hasConcept C2778750930 @default.
- W2076149318 hasConcept C2778938600 @default.
- W2076149318 hasConcept C2778981110 @default.
- W2076149318 hasConcept C2781063702 @default.
- W2076149318 hasConcept C71924100 @default.
- W2076149318 hasConcept C88016717 @default.
- W2076149318 hasConcept C98274493 @default.
- W2076149318 hasConceptScore W2076149318C126322002 @default.
- W2076149318 hasConceptScore W2076149318C134018914 @default.
- W2076149318 hasConceptScore W2076149318C170493617 @default.
- W2076149318 hasConceptScore W2076149318C184389661 @default.
- W2076149318 hasConceptScore W2076149318C185592680 @default.