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- W2076157457 abstract "Like animals and plants, multicellular fungi possess cell-to-cell channels (septal pores) that allow intercellular communication and transport. Here, using a combination of MS of Woronin body-associated proteins and a bioinformatics approach that identifies related proteins based on composition and character, we identify 17 septal pore-associated (SPA) proteins that localize to the septal pore in rings and pore-centered foci. SPA proteins are not homologous at the primary sequence level but share overall physical properties with intrinsically disordered proteins. Some SPA proteins form aggregates at the septal pore, and in vitro assembly assays suggest aggregation through a nonamyloidal mechanism involving mainly α-helical and disordered structures. SPA loss-of-function phenotypes include excessive septation, septal pore degeneration, and uncontrolled Woronin body activation. Together, our data identify the septal pore as a complex subcellular compartment and focal point for the assembly of unstructured proteins controlling diverse aspects of intercellular connectivity." @default.
- W2076157457 created "2016-06-24" @default.
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- W2076157457 date "2012-09-06" @default.
- W2076157457 modified "2023-09-27" @default.
- W2076157457 title "Intrinsically disordered proteins aggregate at fungal cell-to-cell channels and regulate intercellular connectivity" @default.
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- W2076157457 doi "https://doi.org/10.1073/pnas.1207467109" @default.
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