FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076157462> ?p ?o ?g. }

• W2076157462 abstract "Protein functions in cells may be activated or modified by the attachment of several kinds of chemical groups. While protein phosphorylation, i.e. the attachment of a phosphoryl (PO$_3^-$) group, is the most studied form of protein modification, and is known to regulate the functions of many proteins, protein behavior can also be modified by nitrosylation, acetylation, methylation, etc. A protein can have multiple modification sites, and display some form of transition only when enough sites are modified. In a previous paper we have modeled the generic equilibrium properties of multisite protein modification (R.Chignola, C. Dalla Pellegrina, A. Del Fabbro, E.Milotti, Physica A {bf 371}, 463 (2006)) and we have shown that it can account both for sharp, robust thresholds and for information transfer between processes with widely separated timescales. Here we use the same concepts to expand that analysis starting from a dynamical description of multisite modification: we give analytical results for the basic dynamics and numerical results in an example where the modification chain is cascaded with a Michaelis-Menten step. We modify the dynamics and analyze an example with realistic phosphorylation/dephosphorylation steps, and give numerical evidence of the independence of the allosteric effect from the details of the attachment-detachment processes. We conclude that multisite protein modification is dynamically equivalent to the classic allosteric effect." @default.
• W2076157462 created "2016-06-24" @default.
• W2076157462 creator A5003355650 @default.
• W2076157462 creator A5060838440 @default.
• W2076157462 creator A5075758928 @default.
• W2076157462 creator A5077463549 @default.
• W2076157462 date "2007-06-01" @default.
• W2076157462 modified "2023-10-02" @default.
• W2076157462 title "Dynamics of allosteric action in multisite protein modification" @default.
• W2076157462 cites W1595140410 @default.
• W2076157462 cites W1859306058 @default.
• W2076157462 cites W1977306646 @default.
• W2076157462 cites W1981467491 @default.
• W2076157462 cites W1985633388 @default.
• W2076157462 cites W1988791304 @default.
• W2076157462 cites W1998093640 @default.
• W2076157462 cites W2025531537 @default.
• W2076157462 cites W2033443827 @default.
• W2076157462 cites W2049967797 @default.
• W2076157462 cites W2067077009 @default.
• W2076157462 cites W2080593071 @default.
• W2076157462 cites W2082785563 @default.
• W2076157462 cites W2109117831 @default.
• W2076157462 cites W2122123529 @default.
• W2076157462 cites W2126464248 @default.
• W2076157462 cites W2150109730 @default.
• W2076157462 cites W2152342383 @default.
• W2076157462 cites W2155418451 @default.
• W2076157462 cites W2158969445 @default.
• W2076157462 cites W2161545898 @default.
• W2076157462 doi "https://doi.org/10.1016/j.physa.2006.12.034" @default.
• W2076157462 hasPublicationYear "2007" @default.
• W2076157462 type Work @default.
• W2076157462 sameAs 2076157462 @default.
• W2076157462 citedByCount "6" @default.
• W2076157462 countsByYear W20761574622018 @default.
• W2076157462 crossrefType "journal-article" @default.
• W2076157462 hasAuthorship W2076157462A5003355650 @default.
• W2076157462 hasAuthorship W2076157462A5060838440 @default.
• W2076157462 hasAuthorship W2076157462A5075758928 @default.
• W2076157462 hasAuthorship W2076157462A5077463549 @default.
• W2076157462 hasBestOaLocation W20761574622 @default.
• W2076157462 hasConcept C100631289 @default.
• W2076157462 hasConcept C104317684 @default.
• W2076157462 hasConcept C105795698 @default.
• W2076157462 hasConcept C119157956 @default.
• W2076157462 hasConcept C11960822 @default.
• W2076157462 hasConcept C121332964 @default.
• W2076157462 hasConcept C12554922 @default.
• W2076157462 hasConcept C1276947 @default.
• W2076157462 hasConcept C166342909 @default.
• W2076157462 hasConcept C170493617 @default.
• W2076157462 hasConcept C178666793 @default.
• W2076157462 hasConcept C181199279 @default.
• W2076157462 hasConcept C181912034 @default.
• W2076157462 hasConcept C184133267 @default.
• W2076157462 hasConcept C185592680 @default.
• W2076157462 hasConcept C186060115 @default.
• W2076157462 hasConcept C199185054 @default.
• W2076157462 hasConcept C2775981520 @default.
• W2076157462 hasConcept C33923547 @default.
• W2076157462 hasConcept C35651441 @default.
• W2076157462 hasConcept C47701112 @default.
• W2076157462 hasConcept C55493867 @default.
• W2076157462 hasConcept C86803240 @default.
• W2076157462 hasConceptScore W2076157462C100631289 @default.
• W2076157462 hasConceptScore W2076157462C104317684 @default.
• W2076157462 hasConceptScore W2076157462C105795698 @default.
• W2076157462 hasConceptScore W2076157462C119157956 @default.
• W2076157462 hasConceptScore W2076157462C11960822 @default.
• W2076157462 hasConceptScore W2076157462C121332964 @default.
• W2076157462 hasConceptScore W2076157462C12554922 @default.
• W2076157462 hasConceptScore W2076157462C1276947 @default.
• W2076157462 hasConceptScore W2076157462C166342909 @default.
• W2076157462 hasConceptScore W2076157462C170493617 @default.
• W2076157462 hasConceptScore W2076157462C178666793 @default.
• W2076157462 hasConceptScore W2076157462C181199279 @default.
• W2076157462 hasConceptScore W2076157462C181912034 @default.
• W2076157462 hasConceptScore W2076157462C184133267 @default.
• W2076157462 hasConceptScore W2076157462C185592680 @default.
• W2076157462 hasConceptScore W2076157462C186060115 @default.
• W2076157462 hasConceptScore W2076157462C199185054 @default.
• W2076157462 hasConceptScore W2076157462C2775981520 @default.
• W2076157462 hasConceptScore W2076157462C33923547 @default.
• W2076157462 hasConceptScore W2076157462C35651441 @default.
• W2076157462 hasConceptScore W2076157462C47701112 @default.
• W2076157462 hasConceptScore W2076157462C55493867 @default.
• W2076157462 hasConceptScore W2076157462C86803240 @default.
• W2076157462 hasLocation W20761574621 @default.
• W2076157462 hasLocation W20761574622 @default.
• W2076157462 hasOpenAccess W2076157462 @default.
• W2076157462 hasPrimaryLocation W20761574621 @default.
• W2076157462 hasRelatedWork W1995006029 @default.
• W2076157462 hasRelatedWork W2015372665 @default.
• W2076157462 hasRelatedWork W2076157462 @default.
• W2076157462 hasRelatedWork W2087826959 @default.
• W2076157462 hasRelatedWork W2157337914 @default.
• W2076157462 hasRelatedWork W2290574198 @default.
• W2076157462 hasRelatedWork W2460708314 @default.
• W2076157462 hasRelatedWork W2565777687 @default.

• next