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• W2076162671 abstract "Pharmaceutical Patent AnalystVol. 2, No. 5 CommentaryWIPO Re:Search: a consortium catalyzing research and product development for neglected tropical diseasesJennifer Dent, Roopa Ramamoorthi, Katy Graef, Lisa Marie Nelson &Johannes Christian WichardJennifer Dent* Author for correspondenceBIO Ventures for Global Health, Seattle, WA, USA. Search for more papers by this authorEmail the corresponding author at jdent@bvgh.org, Roopa RamamoorthiBIO Ventures for Global Health, Seattle, WA, USASearch for more papers by this author, Katy GraefBIO Ventures for Global Health, Seattle, WA, USASearch for more papers by this author, Lisa Marie NelsonBIO Ventures for Global Health, Seattle, WA, USASearch for more papers by this author &Johannes Christian WichardWIPO, Geneva, SwitzerlandSearch for more papers by this authorPublished Online:22 Aug 2013https://doi.org/10.4155/ppa.13.49AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleKeywords: BIO Ventures for Global Healthdrug repurposingmalariaschistosomiasisWIPOReferences1 Hotez P. A handful of ‘antipoverty’ vaccines exist for neglected diseases, but the world’s poorest billion people need more. Health Affairs30(6),1080–1087 (2011).Crossref, Google Scholar2 Ekins S, Williams AJ, Krasowski MD et al.In silico repositioning of approved drugs for rare and neglected diseases. Drug Discov. Today.16(7–8),298–310 (2011).Crossref, Medline, Google Scholar3 Gloeckner C, Garner AL, Mersha F et al. Repositioning of an existing drug for the neglected tropical disease Onchocerciasis. Proc. Natl Acad. Sci. USA107(8),3424–3429 (2010).Crossref, Medline, CAS, Google Scholar4 Keiser J, Utzinger J. Antimalarial in the treatment of schistosomiasis. Curr. Pharm. Des.18(24),3531–3538 (2012).Medline, CAS, Google Scholar5 Patel G, Karver CE, Behera R et al. Kinase scaffold repurposing for neglected disease drug discovery: discovery of an efficacious, lapatanib-derived lead compound for Trypanosomiasis. J. Med. Chem.56(10),3820–3832 (2013).Crossref, Medline, CAS, Google Scholar6 Scheibel LW, Colombani PM, Hess AD et al. Calcium and calmodulin antagonists inhibit human malaria parasite (Plasmodium falciparum): implications for drug design. Proc. Natl Acad. Sci. USA84(20),7310–7314 (1987).Crossref, Medline, CAS, Google Scholar7 Aminakea MN, Arndtb H-D, Pradel G. The proteasome of malaria parasites: a multi-stage drug target for chemotherapeutic intervention?. Int. J. Parasitol. Drugs Drug Resist.2,1–10 (2012).Crossref, Medline, Google Scholar8 Gamo FJ, Sanz LM, Vidal J et al. Thousands of starting points for antimalarial lead identification. Nature465,305–310 (2010).Crossref, Medline, CAS, Google Scholar101 The Truly Staggering Cost of Inventing New Drugs. www.forbes.com/sites/matthewherper/2012/02/10/the-truly-staggering-cost-of-inventing-new-drugsGoogle Scholar102 WIPO. www.wipo.int/portal/index.html.enGoogle Scholar103 Global Challenges and IP. www.wipo.int/globalchallenges/enGoogle Scholar104 WIPO Re:Search Database. www.wipo.int/research/en/searchGoogle Scholar105 WHO malaria fact sheet. www.who.int/mediacentre/factsheets/fs094/enGoogle Scholar106 WHO schistosomiasis fact sheet. www.who.int/mediacentre/factsheets/fs115/enGoogle Scholar107 WHO diarrheal disease fact sheet. www.who.int/mediacentre/factsheets/fs330/enGoogle Scholar108 WHO disease fact sheet index. www.who.int/mediacentre/factsheets/enGoogle Scholar109 First WHO report on neglected tropical diseases. www.who.int/neglected_diseases/2010report/enGoogle Scholar110 Global Health Observatory Data Repository. http://apps.who.int/gho/data/view.mainGoogle Scholar111 G-Finder Public Search Tool. http://g-finder.policycures.org/gfinder_reportGoogle ScholarFiguresReferencesRelatedDetailsCited ByWIPO Re:Search—A Platform for Product-Centered Cross-Sector Partnerships for the Elimination of Schistosomiasis9 January 2019 | Tropical Medicine and Infectious Disease, Vol. 4, No. 1Fostering innovative product development for neglected tropical diseases through partnershipsAmy Starr, Katy M Graef & Jennifer Dent4 November 2016 | Pharmaceutical Patent Analyst, Vol. 5, No. 6Drug repositioning approaches to parasitic diseases: a medicinal chemistry perspectiveDrug Discovery Today, Vol. 21, No. 10Repurposing pharma assets: an accelerated mechanism for strengthening the schistosomiasis drug development pipelineRoopa Ramamoorthi, Katy M Graef & Jennifer Dent21 May 2015 | Future Medicinal Chemistry, Vol. 7, No. 6The Pharmaceutical Commons11 July 2014 | Science, Technology, & Human Values, Vol. 40, No. 1WIPO Re:Search: Accelerating anthelmintic development through cross-sector partnershipsInternational Journal for Parasitology: Drugs and Drug Resistance, Vol. 4, No. 3Emerging and Reemerging Neglected Tropical Diseases: a Review of Key Characteristics, Risk Factors, and the Policy and Innovation EnvironmentClinical Microbiology Reviews, Vol. 27, No. 4Creating, Managing, and Advancing Collaborations: The Road to Successful Partnerships Vol. 2, No. 5 Follow us on social media for the latest updates Metrics Downloaded 49 times History Published online 22 August 2013 Published in print September 2013 Information© Future Science LtdKeywordsBIO Ventures for Global Healthdrug repurposingmalariaschistosomiasisWIPOAcknowledgementsThe authors thank Eisai, Merck, Pfizer, Sanofi and the WIPO for their review and helpful suggestions.DisclaimerThe views and opinions expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the WIPO.Financial & competing interests disclosureJ Dent, R Ramamoorthi, K Graef and LM Nelson are employees of BIO Ventures for Global Health, which receives WIPO Re:Search sponsorship funding from Alnylam, AstraZeneca, Eisai, GlaxoSmithKline, Merck, Novartis, Pfizer and Sanofi. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download" @default.
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