Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076166312> ?p ?o ?g. }
- W2076166312 endingPage "748" @default.
- W2076166312 startingPage "734" @default.
- W2076166312 abstract "During a scientific workshop the use of biological monitoring in characterization of retrospective exposure assessment was discussed. The workshop addressed currently available methodology and also novel approaches such as in different fields of 'omics'. For use in epidemiology requiring retrospective exposure assessment, biomarker levels should not vary too much over time. If variability in exposure over time is large and differences in exposure between individuals are relatively small, this may lead to underestimation of the exposure-response relationship. This means that, for a sound assessment of health risk, biomarkers that reflect cumulative exposure over a long period of time are preferred over biomarkers with short half-lives. Most of the existing biomarkers such as metabolites in body fluids usually have rather short half-lives, typically less than 1-2 days. Some adducts to DNA show somewhat longer half-lives. The current limit to persistence of biomarkers reflecting cumulative exposure over time is from adducts to haemoglobin with a half-life of 4 months. Some specific organic substances may be more persistent due to storage in adipose tissue or metals in kidneys, nails and hair. The metabonomics, proteomics and present gene expression profiling approaches do not provide a perspective to the availability of more persistent biomarkers and most approaches discussed to date show that it is difficult to interpret study outcomes in terms of exposure to a specific xenobiotic factor. Research efforts should focus on improvement and validation of currently available approaches in the field of addition products to DNA and proteins. Promising new developments may be phosphotriester DNA adducts and adducts to more long-lived proteins such as histones." @default.
- W2076166312 created "2016-06-24" @default.
- W2076166312 creator A5038739372 @default.
- W2076166312 date "2008-01-01" @default.
- W2076166312 modified "2023-10-08" @default.
- W2076166312 title "The use of biomarkers for improved retrospective exposure assessment in epidemiological studies: summary of an ECETOC workshop" @default.
- W2076166312 cites W1965262464 @default.
- W2076166312 cites W1970868126 @default.
- W2076166312 cites W1979264461 @default.
- W2076166312 cites W1982448585 @default.
- W2076166312 cites W1985923772 @default.
- W2076166312 cites W1988236914 @default.
- W2076166312 cites W1989681006 @default.
- W2076166312 cites W1993458021 @default.
- W2076166312 cites W2007470097 @default.
- W2076166312 cites W2010225122 @default.
- W2076166312 cites W2018150264 @default.
- W2076166312 cites W2018955638 @default.
- W2076166312 cites W2024675985 @default.
- W2076166312 cites W2033714771 @default.
- W2076166312 cites W2047810781 @default.
- W2076166312 cites W2053457966 @default.
- W2076166312 cites W2070312499 @default.
- W2076166312 cites W2072083287 @default.
- W2076166312 cites W2072821122 @default.
- W2076166312 cites W2080378175 @default.
- W2076166312 cites W2088144278 @default.
- W2076166312 cites W2096979824 @default.
- W2076166312 cites W2105499761 @default.
- W2076166312 cites W2107140582 @default.
- W2076166312 cites W2107461659 @default.
- W2076166312 cites W2108255671 @default.
- W2076166312 cites W2111888749 @default.
- W2076166312 cites W2132304035 @default.
- W2076166312 cites W2138649409 @default.
- W2076166312 cites W2138876243 @default.
- W2076166312 cites W2143658931 @default.
- W2076166312 cites W2153136738 @default.
- W2076166312 cites W2153589322 @default.
- W2076166312 cites W399779095 @default.
- W2076166312 cites W4247938048 @default.
- W2076166312 doi "https://doi.org/10.1080/13547500802528630" @default.
- W2076166312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18985470" @default.
- W2076166312 hasPublicationYear "2008" @default.
- W2076166312 type Work @default.
- W2076166312 sameAs 2076166312 @default.
- W2076166312 citedByCount "14" @default.
- W2076166312 countsByYear W20761663122012 @default.
- W2076166312 countsByYear W20761663122013 @default.
- W2076166312 countsByYear W20761663122014 @default.
- W2076166312 countsByYear W20761663122015 @default.
- W2076166312 countsByYear W20761663122016 @default.
- W2076166312 countsByYear W20761663122019 @default.
- W2076166312 countsByYear W20761663122021 @default.
- W2076166312 countsByYear W20761663122023 @default.
- W2076166312 crossrefType "journal-article" @default.
- W2076166312 hasAuthorship W2076166312A5038739372 @default.
- W2076166312 hasConcept C104317684 @default.
- W2076166312 hasConcept C111919701 @default.
- W2076166312 hasConcept C12174686 @default.
- W2076166312 hasConcept C124535831 @default.
- W2076166312 hasConcept C142724271 @default.
- W2076166312 hasConcept C167135981 @default.
- W2076166312 hasConcept C187191949 @default.
- W2076166312 hasConcept C198408306 @default.
- W2076166312 hasConcept C2781197716 @default.
- W2076166312 hasConcept C33070731 @default.
- W2076166312 hasConcept C38652104 @default.
- W2076166312 hasConcept C41008148 @default.
- W2076166312 hasConcept C42407357 @default.
- W2076166312 hasConcept C46111723 @default.
- W2076166312 hasConcept C54355233 @default.
- W2076166312 hasConcept C60644358 @default.
- W2076166312 hasConcept C70721500 @default.
- W2076166312 hasConcept C71924100 @default.
- W2076166312 hasConcept C86803240 @default.
- W2076166312 hasConcept C99454951 @default.
- W2076166312 hasConceptScore W2076166312C104317684 @default.
- W2076166312 hasConceptScore W2076166312C111919701 @default.
- W2076166312 hasConceptScore W2076166312C12174686 @default.
- W2076166312 hasConceptScore W2076166312C124535831 @default.
- W2076166312 hasConceptScore W2076166312C142724271 @default.
- W2076166312 hasConceptScore W2076166312C167135981 @default.
- W2076166312 hasConceptScore W2076166312C187191949 @default.
- W2076166312 hasConceptScore W2076166312C198408306 @default.
- W2076166312 hasConceptScore W2076166312C2781197716 @default.
- W2076166312 hasConceptScore W2076166312C33070731 @default.
- W2076166312 hasConceptScore W2076166312C38652104 @default.
- W2076166312 hasConceptScore W2076166312C41008148 @default.
- W2076166312 hasConceptScore W2076166312C42407357 @default.
- W2076166312 hasConceptScore W2076166312C46111723 @default.
- W2076166312 hasConceptScore W2076166312C54355233 @default.
- W2076166312 hasConceptScore W2076166312C60644358 @default.
- W2076166312 hasConceptScore W2076166312C70721500 @default.
- W2076166312 hasConceptScore W2076166312C71924100 @default.
- W2076166312 hasConceptScore W2076166312C86803240 @default.
- W2076166312 hasConceptScore W2076166312C99454951 @default.
- W2076166312 hasIssue "7-8" @default.