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• W2076167801 abstract "Introduction: Valproic acid (VPA) has been used in clinical practice as an anticonvulsant for more than four decades. Its pharmacokinetics and toxicity are thus well documented. VPA is also a potent class-selective histone deacetylase (HDAC) inhibitor at nontoxic therapeutic concentrations. New areas of application for VPA are currently opening up in clinical practice. Areas covered: The authors discuss VPA and how it may serve as an effective drug for cancer therapy. This is due to its ability to induce differentiation of a number of cancer cells in vitro and also to decrease tumor growth and metastases in animal models. The authors highlight how the utilization of VPA as an HDAC inhibitor is not limited to a single-agent therapy. Early clinical studies have also revealed promising potency of VPA in combination treatment with classic anticancer drugs. The authors do this by summarizing the published results and providing insight into the potential future developments for this field. Expert opinion: VPA was shown to restore or improve responsiveness of tumors to conventional therapeutic agents, to enhance the efficacy of adenoviral gene therapy, to sensitize TRAIL-resistant tumor cells to apoptosis, and to enhance radiosensitivity of tumor cells. Drawbacks in VPA medical applications include its teratogenicity and complexity of its effects." @default.
• W2076167801 created "2016-06-24" @default.
• W2076167801 creator A5019949740 @default.
• W2076167801 creator A5034157471 @default.
• W2076167801 creator A5053563084 @default.
• W2076167801 date "2013-10-28" @default.
• W2076167801 modified "2023-10-17" @default.
• W2076167801 title "New perspectives of valproic acid in clinical practice" @default.
• W2076167801 cites W1527985047 @default.
• W2076167801 cites W1599228332 @default.
• W2076167801 cites W1769808657 @default.
• W2076167801 cites W1964363319 @default.
• W2076167801 cites W1966649086 @default.
• W2076167801 cites W1969161297 @default.
• W2076167801 cites W1975692560 @default.
• W2076167801 cites W1978279661 @default.
• W2076167801 cites W1980477780 @default.
• W2076167801 cites W1980626135 @default.
• W2076167801 cites W1984871811 @default.
• W2076167801 cites W1985391665 @default.
• W2076167801 cites W1986095118 @default.
• W2076167801 cites W1987172374 @default.
• W2076167801 cites W1987366741 @default.
• W2076167801 cites W1993712190 @default.
• W2076167801 cites W1997154923 @default.
• W2076167801 cites W2002698073 @default.
• W2076167801 cites W2005127084 @default.
• W2076167801 cites W2005735730 @default.
• W2076167801 cites W2007434627 @default.
• W2076167801 cites W2008333108 @default.
• W2076167801 cites W2008840709 @default.
• W2076167801 cites W2010594589 @default.
• W2076167801 cites W2010995414 @default.
• W2076167801 cites W2014852322 @default.
• W2076167801 cites W2019083542 @default.
• W2076167801 cites W2024161975 @default.
• W2076167801 cites W2029148944 @default.
• W2076167801 cites W2033938104 @default.
• W2076167801 cites W2035461158 @default.
• W2076167801 cites W2035711389 @default.
• W2076167801 cites W2035915355 @default.
• W2076167801 cites W2039437545 @default.
• W2076167801 cites W2040418863 @default.
• W2076167801 cites W2041789504 @default.
• W2076167801 cites W2050931169 @default.
• W2076167801 cites W2055303877 @default.
• W2076167801 cites W2056774542 @default.
• W2076167801 cites W2059134795 @default.
• W2076167801 cites W2063862684 @default.
• W2076167801 cites W2064310618 @default.
• W2076167801 cites W2069688091 @default.
• W2076167801 cites W2070164024 @default.
• W2076167801 cites W2071888464 @default.
• W2076167801 cites W2078454854 @default.
• W2076167801 cites W2080251319 @default.
• W2076167801 cites W2082629538 @default.
• W2076167801 cites W2089140779 @default.
• W2076167801 cites W2089695293 @default.
• W2076167801 cites W2089898032 @default.
• W2076167801 cites W2098012859 @default.
• W2076167801 cites W2098249941 @default.
• W2076167801 cites W2103063189 @default.
• W2076167801 cites W2103665811 @default.
• W2076167801 cites W2106775330 @default.
• W2076167801 cites W2108743126 @default.
• W2076167801 cites W2116478273 @default.
• W2076167801 cites W2117487291 @default.
• W2076167801 cites W2117691193 @default.
• W2076167801 cites W2124458807 @default.
• W2076167801 cites W2128151020 @default.
• W2076167801 cites W2130029734 @default.
• W2076167801 cites W2133653334 @default.
• W2076167801 cites W2135085078 @default.
• W2076167801 cites W2135830745 @default.
• W2076167801 cites W2143438415 @default.
• W2076167801 cites W2146399575 @default.
• W2076167801 cites W2148147266 @default.
• W2076167801 cites W2148232503 @default.
• W2076167801 cites W2151318390 @default.
• W2076167801 cites W2154726890 @default.
• W2076167801 cites W2162895462 @default.
• W2076167801 cites W2165455805 @default.
• W2076167801 cites W2165638033 @default.
• W2076167801 cites W2166082601 @default.
• W2076167801 cites W4251012162 @default.
• W2076167801 cites W2069046240 @default.
• W2076167801 doi "https://doi.org/10.1517/13543784.2013.853037" @default.
• W2076167801 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24160174" @default.
• W2076167801 hasPublicationYear "2013" @default.
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