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• W2076170375 abstract "The large amplitude swelling of liver mitochondria induced by inorganic phosphate is inhibited by ADP and oligomycin and not by atractyloside. The swelling effect of arsenate is also prevented by ADP. The phosphate induced swelling is prevented by dinitrophenol. The protecting effect of dinitrophenol is dependent on the concentrations of phosphate. Competition between phosphate and dinitrophenol on ATP synthesis has been observed. Dinitrophenol promotes swelling of oligomycin supplemented mitochondria. The swelling effect of dinitrophenol is abolished by ADP and rotenone and restored by vitamin K3. Addition of ATP to terminally inhibited liver mitochondria in the presence of Ca2+ and Pi causes large amplitude swelling. Swelling is also obtained by adding ATP in the presence of the SH inhibitor, N-ethylmaleimide. When albumin, is omitted from the medium, ATP causes swelling in the absence of Pi, Ca2+ or N-ethylmaleimide, although these compounds accelerate the swelling process. The large amplitude swelling caused by ATP is abolished by oligomycin, dinitrophenol and ADP and shows a large temperature coefficient." @default.
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• W2076170375 date "1965-01-01" @default.
• W2076170375 modified "2023-10-17" @default.
• W2076170375 title "Swelling and shrinkage phenomena in liver mitochondria I. Large amplitude swelling induced by inorganic phosphate and by ATP" @default.
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• W2076170375 doi "https://doi.org/10.1016/s0926-6593(65)80150-3" @default.
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