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- W2076170876 abstract "STKESchwann cells of the peripheral nervous system express periaxin, a cytosolic protein that contains a PDZ domain, a hallmark of adaptor proteins that assemble macromolecular signaling complexes. Mutations in the human periaxin gene cause the demyelinating neuropathy of Charcot-Marie-Tooth disease, and mice that lack functional periaxin develop a similar condition. Sherman et al. show that periaxin associates with a cytoplasmic protein, dystrophin-related protein 2, which binds to dystroglycan, the cell surface receptor for extracellular matrix molecules. Periaxin forms PDZ domain-mediated dimers and hence clusters the associated dystrophin-glycoprotein complexes at the surface of Schwann cells. Disruption of this clustering destroys dystroglycan organization, thus affecting neuron-Schwann cell interaction and myelin sheath integrity. — LDC Neuron 30 , 677 (2001)." @default.
- W2076170876 created "2016-06-24" @default.
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- W2076170876 date "2001-07-06" @default.
- W2076170876 modified "2023-09-24" @default.
- W2076170876 title "STKE: Stabilizing the Myelin Sheath" @default.
- W2076170876 doi "https://doi.org/10.1126/science.293.5527.17c" @default.
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