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• W2076171916 startingPage "421" @default.
• W2076171916 abstract "T cell activation requires contact with APCs. We used optical techniques to demonstrate T cell polarity on the basis of shape, motility, and localized sensitivity to antigen. An intracellular Ca2+ clamp showed that T cell shape and motility are extremely sensitive to changes in [Ca2+]i (Kd = 200 nM), with immobilization and rounding occurring via a calcineurin-independent pathway. Ca2+-dependent immobilization prolonged T cell contact with the antigen-presenting B cell; buffering the [Ca2+]i signal prevented the formation of stable cell pairs. Optical tweezers revealed spatial T cell sensitivity to antigen by controlling placement on the T cell surface of either B cells or α-CD3 MAb-coated beads. T cells were 4-fold more sensitive to contact made at the leading edge of the T cell compared with the tail. We conclude that motile T cells are polarized antigen sensors that respond physically to [Ca2+]i signals to stabilize their interaction with APCs." @default.
• W2076171916 created "2016-06-24" @default.
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• W2076171916 date "1996-05-01" @default.
• W2076171916 modified "2023-10-17" @default.
• W2076171916 title "Polarity of T Cell Shape, Motility, and Sensitivity to Antigen" @default.
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• W2076171916 doi "https://doi.org/10.1016/s1074-7613(00)80409-4" @default.
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