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- W2076173712 abstract "<h3>Abstract</h3> Polycomb-group (PcG) proteins mediate epigenetic gene regulation by setting H3K27me3 via Polycomb Repressive Complex 2 (PRC2). In plants, it is largely unclear how PcG proteins are recruited to their target genes. Here, we identified the PWWP-DOMAIN INTERACTOR OF POLYCOMBS1 (PWO1) protein which interacts with all three <i>Arabidopsis</i> PRC2 histone methyltransferases and is required for keeping full H3 occupancy at several Arabidopsis genes. PWO1 localizes and recruits CLF to nuclear speckles in tobacco nuclei, suggesting a role in spatial organization of PcG regulation. <i>PWO1</i> belongs to a gene family with three members acting redundantly: <i>pwo1 pwo2 pwo3</i> triple mutants are seedling lethal and show shoot and root meristem arrest, while <i>pwo1</i> single mutants are early flowering. Interestingly, PWO1’s PWWP domain confers binding to histones, which is reduced by a point mutation in a highly conserved residue of this domain and blocked by phosphorylation of H3S28. PWO1 carrying this mutation is not able to fully complement the <i>pwo1 pwo2 pwo3</i> triple mutant, indicating the requirement of this domain for PWO1 <i>in vivo</i> activity. Thus, the PWO family may present a novel class of histone readers which are involved in recruiting PcG proteins to subnuclear domains and in promoting Arabidopsis development." @default.
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- W2076173712 date "1986-12-01" @default.
- W2076173712 modified "2023-09-27" @default.
- W2076173712 title "The diagnosis and management of food allergy" @default.
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- W2076173712 doi "https://doi.org/10.1136/adc.61.12.1247" @default.
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