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- W2076174476 abstract "Observations of functional adenosine triphosphate (ATP)-dependent drug efflux in certain multidrug-resistant cancer cell lines without overexpression of P-glycoprotein or multidrug resistance protein (MRP) family members suggested the existence of another ATP-binding cassette (ABC) transporter capable of causing cancer drug resistance. In one such cell line (MCF-7/AdrVp), the overexpression of a novel member of the G subfamily of ABC transporters was found. The new transporter was termed the breast cancer resistance protein (BCRP), because of its identification in MCF-7 human breast carcinoma cells. BCRP is a 655 amino-acid polypeptide, formally designated as ABCG2. Like all members of the ABC G (white) subfamily, BCRP is a half transporter. Transfection and enforced overexpression of BCRP in drug-sensitive MCF-7 or MDA-MB-231 cells recapitulates the drug-resistance phenotype of MCF-7/AdrVp cells, consistent with current evidence suggesting that functional BCRP is a homodimer. BCRP maps to chromosome 4q22, downstream from a TATA-less promoter. The spectrum of anticancer drugs effluxed by BCRP includes mitoxantrone, camptothecin-derived and indolocarbazole topoisomerase I inhibitors, methotrexate, flavopiridol, and quinazoline ErbB1 inhibitors. Transport of anthracyclines is variable and appears to depend on the presence of a BCRP mutation at codon 482. Potent and specific inhibitors of BCRP are now being developed, opening the door to clinical applications of BCRP inhibition. Owing to tissue localization in the placenta, bile canaliculi, colon, small bowel, and brain microvessel endothelium, BCRP may play a role in protecting the organism from potentially harmful xenobiotics. BCRP expression has also been demonstrated in pluripotential ‘side population’ stem cells, responsible for the characteristic ability of these cells to exclude Hoechst 33342 dye, and possibly for the maintenance of the stem cell phenotype. Studies are emerging on the role of BCRP expression in drug resistance in clinical cancers. More prospective studies are needed, preferably combining BCRP protein or mRNA quantification with functional assays, in order to determine the contribution of BCRP to drug resistance in human cancers." @default.
- W2076174476 created "2016-06-24" @default.
- W2076174476 creator A5035497669 @default.
- W2076174476 creator A5062642084 @default.
- W2076174476 date "2003-10-20" @default.
- W2076174476 modified "2023-10-18" @default.
- W2076174476 title "Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)" @default.
- W2076174476 cites W1481699366 @default.
- W2076174476 cites W1483167997 @default.
- W2076174476 cites W1495058242 @default.
- W2076174476 cites W1497498736 @default.
- W2076174476 cites W1509359478 @default.
- W2076174476 cites W1523946871 @default.
- W2076174476 cites W1586955534 @default.
- W2076174476 cites W1965129145 @default.
- W2076174476 cites W1967003022 @default.
- W2076174476 cites W1967069846 @default.
- W2076174476 cites W1971274721 @default.
- W2076174476 cites W1972764534 @default.
- W2076174476 cites W1976915106 @default.
- W2076174476 cites W1977668920 @default.
- W2076174476 cites W1980132014 @default.
- W2076174476 cites W1982341204 @default.
- W2076174476 cites W1985349868 @default.
- W2076174476 cites W1986040702 @default.
- W2076174476 cites W1986944635 @default.
- W2076174476 cites W1990932902 @default.
- W2076174476 cites W1993494709 @default.
- W2076174476 cites W1996429641 @default.
- W2076174476 cites W1997755898 @default.
- W2076174476 cites W2000351395 @default.
- W2076174476 cites W2002908445 @default.
- W2076174476 cites W2008902935 @default.
- W2076174476 cites W2010623159 @default.
- W2076174476 cites W2014020178 @default.
- W2076174476 cites W2020441233 @default.
- W2076174476 cites W2021155660 @default.
- W2076174476 cites W2021428758 @default.
- W2076174476 cites W2023345325 @default.
- W2076174476 cites W2024096384 @default.
- W2076174476 cites W2028533496 @default.
- W2076174476 cites W2031533238 @default.
- W2076174476 cites W2031785769 @default.
- W2076174476 cites W2036337617 @default.
- W2076174476 cites W2036459315 @default.
- W2076174476 cites W2041995665 @default.
- W2076174476 cites W2044874551 @default.
- W2076174476 cites W2046792018 @default.
- W2076174476 cites W2047732042 @default.
- W2076174476 cites W2048161767 @default.
- W2076174476 cites W2048558726 @default.
- W2076174476 cites W2050007442 @default.
- W2076174476 cites W2051727820 @default.
- W2076174476 cites W2052209393 @default.
- W2076174476 cites W2056598800 @default.
- W2076174476 cites W2063248963 @default.
- W2076174476 cites W2063291817 @default.
- W2076174476 cites W2067339592 @default.
- W2076174476 cites W2068962067 @default.
- W2076174476 cites W2070691527 @default.
- W2076174476 cites W2071025146 @default.
- W2076174476 cites W2072046272 @default.
- W2076174476 cites W2072106056 @default.
- W2076174476 cites W2077541106 @default.
- W2076174476 cites W2077673548 @default.
- W2076174476 cites W2078392360 @default.
- W2076174476 cites W2081507321 @default.
- W2076174476 cites W2084482244 @default.
- W2076174476 cites W2091408415 @default.
- W2076174476 cites W2097382368 @default.
- W2076174476 cites W2098137059 @default.
- W2076174476 cites W2118207487 @default.
- W2076174476 cites W2118667947 @default.
- W2076174476 cites W2138198587 @default.
- W2076174476 cites W2142024216 @default.
- W2076174476 cites W2150485214 @default.
- W2076174476 cites W2156280292 @default.
- W2076174476 cites W2165070790 @default.
- W2076174476 cites W2166082449 @default.
- W2076174476 cites W2168070336 @default.
- W2076174476 cites W2168471377 @default.
- W2076174476 cites W2319622120 @default.
- W2076174476 cites W2321260470 @default.
- W2076174476 cites W2321387150 @default.
- W2076174476 cites W2414957002 @default.
- W2076174476 cites W3022385516 @default.
- W2076174476 doi "https://doi.org/10.1038/sj.onc.1206938" @default.
- W2076174476 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14576842" @default.
- W2076174476 hasPublicationYear "2003" @default.
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