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- W2076175094 abstract "Screening of various agents resulted in the identification of 5-methyl-1,2,3,4-tetrahydro-gamma-carboline (1; K(i)=5,300 nM) as a compound with modest affinity for mouse 5-HT(5A) receptors. Structure-affinity studies were conducted resulting in 5-methyl-2-[3-(4-fluorophenoxy)propyl]-1,2,3,4-tetrahydro-gamma-carboline (17; K(i)=13 nM). Although 17 also binds at 5-HT(2) receptors, it serves as a novel lead for the further development of 5-HT(5A) ligands." @default.
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- W2076175094 date "2003-03-01" @default.
- W2076175094 modified "2023-09-27" @default.
- W2076175094 title "γ-Carbolines: binding at 5-HT5A serotonin receptors" @default.
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- W2076175094 doi "https://doi.org/10.1016/s0968-0896(02)00527-8" @default.
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