Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076176960> ?p ?o ?g. }
- W2076176960 endingPage "703" @default.
- W2076176960 startingPage "693" @default.
- W2076176960 abstract "Senescence of growth-arrested Escherichia coli cells is like mandatory aging in higher eukaryotes, accompanied by increased oxidative modifications of macromolecules. Similar to aged flies, this senescence-related oxidation targets enzymes of the Krebs cycle. Additional targets include the universal stress protein A, the Hsp70 chaperone DnaK, translation elongation factors, and histone-like proteins. However, during the early stages of stasis, protein oxidation is more general and affects a large number of proteins. Attempts to correlate this protein oxidation with a reduced activity of the antioxidant defense systems or an increased tendency of the respiratory apparatus to produce reactive oxygen species (ROS) have generated conflicting results. Instead, recent data indicate that oxidation of proteins may occur in the absence of an increased oxidative stress and is rather caused by an increased production of substrates available for oxidative attack. Misfolded and aberrant proteins appear to be such substrates and the production of aberrant polypeptides surge during the early stages of stasis due to a reduced translational fidelity. The data point to a novel mechanism involved in protein oxidation that has not been considered previously in aging research." @default.
- W2076176960 created "2016-06-24" @default.
- W2076176960 creator A5041540706 @default.
- W2076176960 date "2002-09-01" @default.
- W2076176960 modified "2023-10-16" @default.
- W2076176960 title "Translational fidelity, protein oxidation, and senescence: lessons from bacteria" @default.
- W2076176960 cites W149745650 @default.
- W2076176960 cites W1519787449 @default.
- W2076176960 cites W1569077780 @default.
- W2076176960 cites W1608860139 @default.
- W2076176960 cites W1778633979 @default.
- W2076176960 cites W1826343793 @default.
- W2076176960 cites W1842692201 @default.
- W2076176960 cites W1919248975 @default.
- W2076176960 cites W1976051634 @default.
- W2076176960 cites W1978933175 @default.
- W2076176960 cites W1987634519 @default.
- W2076176960 cites W1989744507 @default.
- W2076176960 cites W1990945027 @default.
- W2076176960 cites W1993091967 @default.
- W2076176960 cites W1997736987 @default.
- W2076176960 cites W2003566943 @default.
- W2076176960 cites W2004256161 @default.
- W2076176960 cites W2005029264 @default.
- W2076176960 cites W2009812778 @default.
- W2076176960 cites W2033231044 @default.
- W2076176960 cites W2035849178 @default.
- W2076176960 cites W2036910681 @default.
- W2076176960 cites W2037752610 @default.
- W2076176960 cites W2049151505 @default.
- W2076176960 cites W2052046277 @default.
- W2076176960 cites W2061429668 @default.
- W2076176960 cites W2062776142 @default.
- W2076176960 cites W2071228240 @default.
- W2076176960 cites W2073475312 @default.
- W2076176960 cites W2076510866 @default.
- W2076176960 cites W2077691416 @default.
- W2076176960 cites W2087324903 @default.
- W2076176960 cites W2087432006 @default.
- W2076176960 cites W2099944515 @default.
- W2076176960 cites W2107919301 @default.
- W2076176960 cites W2113007696 @default.
- W2076176960 cites W2115997681 @default.
- W2076176960 cites W2116910668 @default.
- W2076176960 cites W2122952856 @default.
- W2076176960 cites W2124786260 @default.
- W2076176960 cites W2133560060 @default.
- W2076176960 cites W2149686421 @default.
- W2076176960 cites W2167228645 @default.
- W2076176960 cites W2167639596 @default.
- W2076176960 cites W2168989431 @default.
- W2076176960 cites W2218000086 @default.
- W2076176960 cites W2315512556 @default.
- W2076176960 cites W346464200 @default.
- W2076176960 doi "https://doi.org/10.1016/s1568-1637(02)00028-4" @default.
- W2076176960 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12208238" @default.
- W2076176960 hasPublicationYear "2002" @default.
- W2076176960 type Work @default.
- W2076176960 sameAs 2076176960 @default.
- W2076176960 citedByCount "55" @default.
- W2076176960 countsByYear W20761769602012 @default.
- W2076176960 countsByYear W20761769602013 @default.
- W2076176960 countsByYear W20761769602014 @default.
- W2076176960 countsByYear W20761769602015 @default.
- W2076176960 countsByYear W20761769602016 @default.
- W2076176960 countsByYear W20761769602017 @default.
- W2076176960 countsByYear W20761769602018 @default.
- W2076176960 countsByYear W20761769602019 @default.
- W2076176960 countsByYear W20761769602020 @default.
- W2076176960 countsByYear W20761769602021 @default.
- W2076176960 countsByYear W20761769602022 @default.
- W2076176960 countsByYear W20761769602023 @default.
- W2076176960 crossrefType "journal-article" @default.
- W2076176960 hasAuthorship W2076176960A5041540706 @default.
- W2076176960 hasConcept C136238340 @default.
- W2076176960 hasConcept C142724271 @default.
- W2076176960 hasConcept C185592680 @default.
- W2076176960 hasConcept C2775962898 @default.
- W2076176960 hasConcept C2776151105 @default.
- W2076176960 hasConcept C2780829032 @default.
- W2076176960 hasConcept C2911203004 @default.
- W2076176960 hasConcept C3675279 @default.
- W2076176960 hasConcept C48349386 @default.
- W2076176960 hasConcept C522857546 @default.
- W2076176960 hasConcept C55493867 @default.
- W2076176960 hasConcept C57600042 @default.
- W2076176960 hasConcept C71924100 @default.
- W2076176960 hasConcept C86803240 @default.
- W2076176960 hasConcept C95444343 @default.
- W2076176960 hasConceptScore W2076176960C136238340 @default.
- W2076176960 hasConceptScore W2076176960C142724271 @default.
- W2076176960 hasConceptScore W2076176960C185592680 @default.
- W2076176960 hasConceptScore W2076176960C2775962898 @default.
- W2076176960 hasConceptScore W2076176960C2776151105 @default.
- W2076176960 hasConceptScore W2076176960C2780829032 @default.
- W2076176960 hasConceptScore W2076176960C2911203004 @default.
- W2076176960 hasConceptScore W2076176960C3675279 @default.
- W2076176960 hasConceptScore W2076176960C48349386 @default.